Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 8/20 | 0.49 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10575682 | 0.91 | HDAC6 (0.40) | NPBWR1DGAT1KCNH2TRPV1NPC1 | |
| SCHEMBL10579334 | 0.85 | DGAT1 (0.64) | NPBWR1DGAT1KCNH2TRPV1SCD | |
| SCHEMBL10574922 | 0.83 | HDAC6 (0.43) | NPBWR1DGAT1KCNH2TRPV1NPC1 | |
| SCHEMBL10577479 | 0.82 | NPBWR1 (0.67) | NPBWR1DGAT1KCNH2TRPV1NPC1 | |
| SCHEMBL10576089 | 0.80 | NPBWR1 (0.64) | NPBWR1DGAT1KCNH2TRPV1NPC1 | |
| SCHEMBL10578018 | 0.80 | DGAT1 (0.62) | NPBWR1DGAT1KCNH2NPC1KDM4E | |
| SCHEMBL10573947 | 0.79 | NPC1 (0.58) | NPBWR1DGAT1KCNH2TRPV1NPC1 | |
| SCHEMBL10573910 | 0.79 | SLC2A1 (0.62) | NPBWR1TRPV1NPC1KDM4EALDH1A1 | |
| SCHEMBL10579204 | 0.77 | ALOX5 (0.62) | NPBWR1TRPV1KDM4EALDH1A1HPGD | |
| SCHEMBL10579325 | 0.76 | DGAT1 (0.51) | NPBWR1DGAT1KCNH2TRPV1SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |