Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.44 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10578757 | 0.89 | KDM4E (0.50) | HDAC6MAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL10574927 | 0.84 | PDE2A (0.50) | MAPTALDH1A1SMN1; SMN2RAB9AHPGD | |
| SCHEMBL10576178 | 0.81 | NPBWR1 (0.46) | NPBWR1HDAC6EGFRCHEK2HPSE | |
| SCHEMBL10575172 | 0.80 | PDE2A (0.35) | HDAC6MAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL10574195 | 0.78 | PKN1 (0.43) | HDAC6MAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL10695060 | 0.75 | NPC1 (0.40) | HDAC6CHEK2HPSEMAPTALDH1A1 | |
| SCHEMBL10577465 | 0.74 | NPBWR1 (0.53) | NPBWR1HDAC6EGFRCHEK2MMP2 | |
| SCHEMBL10574665 | 0.73 | NPBWR1 (0.47) | NPBWR1HDAC6EGFRCHEK2HPSE | |
| SCHEMBL10576194 | 0.72 | NPBWR1 (0.58) | NPBWR1HDAC6EGFRCHEK2HPSE | |
| SCHEMBL21705321 | 0.72 | HDAC6 (0.66) | NPBWR1HDAC6CHEK2HPSEMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |