Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | MPL | P40238 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TNKS | O95271 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10575162 | 0.82 | MTNR1A (0.37) | KDM4EALDH1A1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL10576187 | 0.80 | NPBWR1 (0.46) | KDM4EALDH1A1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL10578757 | 0.80 | KDM4E (0.50) | PDE2AKDM4EALDH1A1RAB9ATP53 | |
| SCHEMBL10574927 | 0.79 | PDE2A (0.50) | PDE2AALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL10695250 | 0.76 | METAP2 (0.38) | KDM4ERAB9ASMN1; SMN2HDAC6NPC1 | |
| SCHEMBL10575751 | 0.75 | METAP2 (0.34) | HDAC6METAP2 | |
| SCHEMBL10575178 | 0.74 | METAP2 (0.42) | KDM4EALDH1A1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL10695060 | 0.72 | NPC1 (0.40) | ALDH1A1RAB9ASMN1; SMN2HDAC6NPC1 | |
| SCHEMBL10574195 | 0.69 | PKN1 (0.43) | PDE2AKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL31154200 | 0.67 | GAA (0.48) | KDM4EALDH1A1RAB9ATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |