Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.34 |
| ▸ | PPARG | P37231 | 6/20 | 0.34 |
| ▸ | PPARD | Q03181 | 6/20 | 0.34 |
| ▸ | PPARA | Q07869 | 6/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.34 |
| ▸ | TLR2 | O60603 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2576010 | 0.77 | LMNA (0.50) | ALDH1A1TSHRHPGDHSD17B10LMNA | |
| SCHEMBL8654462 | 0.76 | ALDH1A1 (0.49) | ALDH1A1TSHRHPGDHSD17B10LMNA | |
| SCHEMBL8654643 | 0.76 | ALDH1A1 (0.49) | ALDH1A1TSHRHPGDHSD17B10LMNA | |
| SCHEMBL8521929 | 0.74 | ALDH1A1 (0.50) | ALDH1A1TSHRHPGDHSD17B10LMNA | |
| SCHEMBL8611028 | 0.72 | ALDH1A1 (0.41) | ALDH1A1TSHRHPGDHSD17B10LMNA | |
| SCHEMBL8652188 | 0.72 | ALDH1A1 (0.51) | ALDH1A1TSHRHPGDHSD17B10LMNA | |
| SCHEMBL7148358 | 0.70 | ALDH1A1 (0.58) | ALDH1A1TSHRHPGDHSD17B10LMNA | |
| SCHEMBL11256668 | 0.69 | ALDH1A1 (0.57) | ALDH1A1TSHRHPGDHSD17B10LMNA | |
| SCHEMBL2580220 | 0.64 | ALDH1A1 (0.67) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL572791 | 0.62 | ALDH1A1 (0.64) | ALDH1A1HPGDLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4868181-A | CALCIUM CHANNEL BLOCKERS, ADRENERGIC BLOCKING AGENTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-09-19 | — | — | US | disclosed |
| EP-0255710-A2 | 1,4-Dihydropyridine derivatives with calcium agonist and alpha-1-antagonist activity | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1988-02-10 | — | — | EP | disclosed |