Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | POLB | P06746 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KIT | P10721 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KLK7 | P49862 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10579971 | 0.92 | NPC1 (0.49) | NPC1RAB9APKMHDAC6KDM4E | |
| SCHEMBL10574912 | 0.89 | MITF (0.37) | NPC1RAB9APKMMITFOPRM1 | |
| SCHEMBL10574665 | 0.87 | NPBWR1 (0.47) | NPC1RAB9AHDAC6KDM4EALDH1A1 | |
| SCHEMBL10574083 | 0.87 | LOXL2 (0.39) | NPC1RAB9APKMHDAC6KDM4E | |
| SCHEMBL10580688 | 0.86 | HDAC6 (0.52) | HDAC6MAPTSMN1; SMN2NPBWR1DGAT1 | |
| SCHEMBL10578682 | 0.85 | MAPT (0.49) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL10578437 | 0.84 | HDAC6 (0.35) | NPC1RAB9AHDAC6KDM4EALDH1A1 | |
| SCHEMBL10571887 | 0.84 | KIT (0.39) | NPC1RAB9AHDAC6KDM4EALDH1A1 | |
| SCHEMBL10578691 | 0.84 | GUSB (0.43) | NPC1RAB9APKMHDAC6KDM4E | |
| SCHEMBL10577985 | 0.84 | NPBWR1 (0.46) | RAB9AHDAC6KITNPBWR1DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |