Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 7/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10574094 | 0.92 | DGAT1 (0.44) | LOXL2DGAT1KCNH2SOAT1ADORA2A | |
| SCHEMBL10579964 | 0.87 | NPC1 (0.49) | DGAT1MAPTKDM4EALDH1A1POLB | |
| SCHEMBL10574912 | 0.86 | MITF (0.37) | DGAT1KCNH2SOAT1MAPTKDM4E | |
| SCHEMBL10574269 | 0.86 | NPC1 (0.48) | ADORA2AMAPTKDM4EALDH1A1POLB | |
| SCHEMBL10576075 | 0.84 | ALOX5 (0.47) | MAPTKDM4EALDH1A1POLBHPGD | |
| SCHEMBL10580688 | 0.83 | HDAC6 (0.52) | DGAT1KCNH2SOAT1MAPTHDAC6 | |
| SCHEMBL10574665 | 0.82 | NPBWR1 (0.47) | MAPTKDM4EALDH1A1CHEK2HDAC6 | |
| SCHEMBL10578437 | 0.82 | HDAC6 (0.35) | MAPTKDM4EALDH1A1HPGDHDAC6 | |
| SCHEMBL10575981 | 0.82 | AMY1A (0.31) | MAPTHDAC6NPC1RAB9A | |
| SCHEMBL10571887 | 0.81 | KIT (0.39) | DGAT1KCNH2MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |