Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 8/20 | 0.75 |
| ▸ | CBFB | Q13951 | 12/20 | 0.67 |
| ▸ | METAP1 | P53582 | 6/20 | 0.61 |
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | PKM | P14618 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.57 |
| ▸ | F2 | P00734 | 1/20 | 0.55 |
| ▸ | F10 | P00742 | 1/20 | 0.55 |
| ▸ | F7 | P08709 | 1/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10580068 | 0.90 | METAP2 (0.60) | METAP2CBFBMETAP1NPC1RAB9A | |
| SCHEMBL10576089 | 0.82 | NPBWR1 (0.64) | METAP2NPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL10695359 | 0.82 | METAP2 (0.66) | METAP2CBFBMETAP1NPC1RAB9A | |
| SCHEMBL10695258 | 0.81 | METAP2 (0.48) | METAP2CBFBMETAP1NPC1RAB9A | |
| SCHEMBL10579303 | 0.79 | KDM4E (0.60) | METAP2CBFBNPC1RAB9AHPGD | |
| SCHEMBL10573947 | 0.79 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL10578018 | 0.77 | DGAT1 (0.62) | METAP2NPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL4181882 | 0.77 | METAP2 (0.81) | METAP2CBFBMETAP1NPC1RAB9A | |
| SCHEMBL4371835 | 0.76 | METAP2 (1.00) | METAP2CBFBMETAP1NPC1RAB9A | |
| SCHEMBL12119033 | 0.76 | CBFB (1.00) | METAP2CBFBMETAP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |