Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.48 |
| ▸ | CBFB | Q13951 | 2/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 5/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10695250 | 0.90 | METAP2 (0.38) | METAP2CBFBNPBWR1TRPV1KMT2A | |
| SCHEMBL10575761 | 0.82 | METAP2 (0.43) | METAP2CBFBNPBWR1KCNH2TRPV1 | |
| SCHEMBL10575178 | 0.81 | METAP2 (0.42) | METAP2CBFBSCN10AGAAMEN1 | |
| SCHEMBL10580080 | 0.81 | METAP2 (0.75) | METAP2CBFBGAAKMT2AMAPT | |
| SCHEMBL10576089 | 0.77 | NPBWR1 (0.64) | METAP2NPBWR1KCNH2TRPV1CHEK2 | |
| SCHEMBL10573947 | 0.76 | NPC1 (0.58) | NPBWR1KCNH2TRPV1PKN2GAA | |
| SCHEMBL10577479 | 0.76 | NPBWR1 (0.67) | NPBWR1KCNH2TRPV1CHEK2SCD | |
| SCHEMBL10579334 | 0.75 | DGAT1 (0.64) | NPBWR1KCNH2TRPV1CHEK1PAK4 | |
| SCHEMBL10573938 | 0.74 | MAPT (0.59) | NPBWR1SCN10AKCNH2GAAMEN1 | |
| SCHEMBL10575692 | 0.74 | NPBWR1 (0.49) | NPBWR1KCNH2TRPV1SCDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |