Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.53 |
| ▸ | CASP2 | P42575 | 1/20 | 0.52 |
| ▸ | NAAA | Q02083 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.42 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21695696 | 0.89 | HIF1A (0.71) | HIF1AKDM4EMAPK1ADRA1APAOX | |
| SCHEMBL28757039 | 0.87 | KDM4E (0.75) | HIF1AKDM4EMAPK1ADRA1APAOX | |
| SCHEMBL22211290 | 0.84 | ADRA1A (0.74) | HIF1AKDM4EMAPK1ADRA1APAOX | |
| SCHEMBL22211311 | 0.84 | CASP2 (0.68) | HIF1AKDM4EMAPK1ADRA1APAOX | |
| SCHEMBL27137140 | 0.84 | CASP2 (0.74) | HIF1AKDM4EMAPK1ADRA1APAOX | |
| SCHEMBL21695694 | 0.83 | KDM4E (0.68) | HIF1AKDM4EMAPK1ADRA1APAOX | |
| SCHEMBL19958499 | 0.82 | PAOX (0.81) | HIF1AKDM4EMAPK1ADRA1APAOX | |
| SCHEMBL22211260 | 0.82 | PAOX (0.81) | HIF1AKDM4EMAPK1ADRA1APAOX | |
| SCHEMBL19150115 | 0.82 | CASP2 (0.77) | HIF1AKDM4EMAPK1ADRA1APAOX | |
| SCHEMBL10432996 | 0.82 | PRMT1 (0.52) | KDM4EMAPK1ADRA1ACASP2NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0346281-A1 | Carbamoylated hydroxamic-acid derivatives, and process for their preparation | CIBA-GEIGY AG (CH) | 1989-12-13 | — | — | EP | disclosed |
| EP-0300966-A2 | Process for the selective N-acylation of amino-hydraxamic and derivates and starting compounds therefor | CIBA-GEIGY AG (CH) | 1989-01-25 | — | — | EP | disclosed |