Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | DHPS | P49366 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8344326 | 0.82 | CYP19A1 (0.54) | CYP19A1ALDH1A1TP53SMN1; SMN2MAPT | |
| SCHEMBL27871329 | 0.79 | IRAK4 (0.43) | METAP2DHPSPDE4ACHRNB4CHRNA3 | |
| SCHEMBL27887540 | 0.79 | PDE4A (0.40) | METAP2DHPSCYP19A1PDE4ACHRNB4 | |
| SCHEMBL10595789 | 0.79 | RAB9A (0.50) | CLK4LMNAMAPK14CYP1A2CYP3A4 | |
| SCHEMBL29786739 | 0.79 | RAB9A (0.50) | CLK4LMNAMAPK14CYP1A2CYP3A4 | |
| SCHEMBL27854208 | 0.79 | KMO (0.44) | CYP3A4TP53MAPT | |
| SCHEMBL782769 | 0.79 | CLK4 (0.52) | METAP2DHPSCYP19A1PDE4ACHRNB4 | |
| SCHEMBL1673203 | 0.77 | LMNA (0.50) | LMNASMN1; SMN2MAPK1MAPT | |
| SCHEMBL10594682 | 0.77 | CYP19A1 (0.36) | CYP19A1CLK4DYRK1ALMNACYP1A2 | |
| SCHEMBL10595730 | 0.76 | CYP1A2 (0.43) | CLK4DYRK1ALMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0132851-B1 | 5-SUBSTITUTED(1,2,4)TRIAZOLO(1,5-C)PYRIMIDIN-2-AMINES | AMERICAN CYANAMID COMPANY (US) | 1989-10-04 | — | — | EP | disclosed |
| US-4579848-A | ANTIASTHMA AGENTS | AMERICAN CYANAMID COMPANY (US) | 1986-04-01 | — | — | US | disclosed |
| EP-0132851-A1 | 5-Substituted(1,2,4)triazolo(1,5-c)pyrimidin-2-amines | AMERICAN CYANAMID COMPANY (US) | 1985-02-13 | — | — | EP | disclosed |