Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8344326 | 0.80 | CYP19A1 (0.54) | CYP19A1ALDH1A1TSHRTP53SMN1; SMN2 | |
| SCHEMBL10594550 | 0.77 | METAP2 (0.40) | CYP19A1CLK4DYRK1ALMNACYP1A2 | |
| SCHEMBL29786739 | 0.77 | RAB9A (0.50) | CLK4LMNACYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL10595789 | 0.77 | RAB9A (0.50) | CLK4LMNACYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL27854208 | 0.77 | KMO (0.44) | CYP3A4MAPKAPK2TP53MAPT | |
| SCHEMBL1673203 | 0.75 | LMNA (0.50) | LMNASMN1; SMN2MAPK1MAPTNPC1 | |
| SCHEMBL25260413 | 0.73 | CLK4 (0.68) | CYP19A1CLK4DYRK1ALMNACYP1A2 | |
| SCHEMBL31230006 | 0.73 | CLK4 (0.68) | CYP19A1CLK4DYRK1ALMNACYP1A2 | |
| SCHEMBL10593988 | 0.73 | DYRK1A (0.46) | CYP19A1CLK4DYRK1ALMNACYP1A2 | |
| SCHEMBL29206336 | 0.73 | KMO (0.48) | DYRK1ACYP1A2CYP3A4ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0132851-B1 | 5-SUBSTITUTED(1,2,4)TRIAZOLO(1,5-C)PYRIMIDIN-2-AMINES | AMERICAN CYANAMID COMPANY (US) | 1989-10-04 | — | — | EP | disclosed |
| US-4579848-A | ANTIASTHMA AGENTS | AMERICAN CYANAMID COMPANY (US) | 1986-04-01 | — | — | US | disclosed |
| EP-0132851-A1 | 5-Substituted(1,2,4)triazolo(1,5-c)pyrimidin-2-amines | AMERICAN CYANAMID COMPANY (US) | 1985-02-13 | — | — | EP | disclosed |