SCHEMBL10596385

SCHEMBL10596385

C=C(CCC1OCCCO1)c1ccc(Cl)cc1Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
ALDH1A1 P00352 2/20 0.37
MAPK1 P28482 1/20 0.37
HIF1A Q16665 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
TSHR P16473 2/20 0.37
CASP1 P29466 1/20 0.37
KDM4E B2RXH2 1/20 0.36
MAPT P10636 1/20 0.36
HPGD P15428 3/20 0.36
USP2 O75604 1/20 0.35
LMNA P02545 1/20 0.35
ALOX15 P16050 1/20 0.35
POLB P06746 1/20 0.35
HSD17B10 Q99714 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10595411 0.83 ALDH1A1 (0.51) CYP3A4CYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL11077787 0.70 MEN1 (0.40) ALDH1A1MAPK1HIF1ASMN1; SMN2TSHR
SCHEMBL9664110 0.70 MAPK1 (0.44) CYP3A4ALDH1A1MAPK1HIF1ASMN1; SMN2
SCHEMBL11077794 0.69 ALDH1A1 (0.39) ALDH1A1MAPK1HIF1ASMN1; SMN2TSHR
SCHEMBL10455909 0.69 ALDH1A1 (0.50) CYP3A4CYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL10594821 0.69 ADRA2C (0.40) CYP1A2SMN1; SMN2HPGDLMNA
SCHEMBL10367993 0.68 ALDH1A1 (0.46) CYP3A4ALDH1A1MAPK1HIF1ASMN1; SMN2
SCHEMBL9664124 0.68 ALDH1A1 (0.50) CYP3A4ALDH1A1MAPK1HIF1ASMN1; SMN2
SCHEMBL992504 0.68 ALDH1A1 (0.48) CYP3A4ALDH1A1MAPK1HIF1ASMN1; SMN2
SCHEMBL8091206 0.68 POLB (0.49) CYP3A4CYP1A2CYP2C9CYP2C19ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0089100-B1 AZOLYL DERIVATIVES AS FUNGICIDES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1989-05-31 EP disclosed
US-4518415-A PLANT GROWTH REGULATORS, FUNGICIDES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1985-05-21 US disclosed
EP-0089100-A2 Azolyl derivatives as fungicides IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-09-21 EP disclosed