Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | NAAA | Q02083 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | CTSG | P08311 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4347123 | 0.82 | RAB9A (0.68) | SMN1; SMN2LMNAALDH1A1HPGDRAB9A | |
| SCHEMBL10596825 | 0.82 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAALDH1A1HPGDRAB9A | |
| SCHEMBL10484573 | 0.82 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNAALDH1A1HPGDRAB9A | |
| SCHEMBL28272030 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAALDH1A1HPGDRAB9A | |
| SCHEMBL15023510 | 0.81 | LMNA (1.00) | SMN1; SMN2LMNAALDH1A1HPGDRAB9A | |
| SCHEMBL14029065 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAALDH1A1HPGDRAB9A | |
| SCHEMBL18878471 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAALDH1A1HPGDRAB9A | |
| Benzene SCHEMBL28248159 | 0.80 | NAAA (0.73) | SMN1; SMN2LMNAALDH1A1HPGDRAB9A | |
| SCHEMBL334957 | 0.80 | NAAA (0.73) | SMN1; SMN2LMNAALDH1A1HPGDRAB9A | |
| SCHEMBL3192014 | 0.79 | LMNA (0.77) | SMN1; SMN2LMNAHPGDRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0339976-B1 | Anti-tumour agents | ICI PLC (GB) | 1994-02-02 | — | — | EP | claimed |
| EP-0339976-A1 | Anti-tumour agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-11-02 | — | — | EP | claimed |
| EP-0339976-B1 | Anti-tumour agents | ICI PLC (GB) | 1994-02-02 | — | — | EP | disclosed |
| EP-0339976-A1 | Anti-tumour agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-11-02 | — | — | EP | disclosed |