Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3237592 | 0.83 | ALDH1A1 (0.47) | ALDH1A1HPGDRAB9APOLBSMN1; SMN2 | |
| SCHEMBL18105957 | 0.76 | KMT2A (0.48) | ALDH1A1L3MBTL1HPGDRAB9APOLB | |
| SCHEMBL224697 | 0.73 | RAB9A (0.44) | ALDH1A1L3MBTL1KDM4EHPGDRAB9A | |
| SCHEMBL19040487 | 0.72 | METAP2 (0.38) | ALDH1A1HPGDRAB9ANPC1TP53 | |
| SCHEMBL13635133 | 0.71 | SMN1; SMN2 (0.53) | HPGDRAB9APOLBSMN1; SMN2NPC1 | |
| SCHEMBL931171 | 0.71 | MEN1 (0.52) | L3MBTL1KDM4ERAB9APOLBTP53 | |
| SCHEMBL15654561 | 0.71 | RAB9A (0.53) | ALDH1A1HPGDRAB9APOLBNPC1 | |
| SCHEMBL7876761 | 0.71 | CYP4F2 (0.47) | ALDH1A1L3MBTL1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL931742 | 0.71 | MAOA (0.52) | ALDH1A1HPGDRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL29171418 | 0.70 | HPGD (0.62) | ALDH1A1L3MBTL1HPGDRAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175325-B1 | NEW 8-SUBSTITUTED NUCLEOSIDE AND PURINE DERIVATIVES, THE PROCESS FOR THE PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Pierrel S.p.A. (IT) | 1989-03-15 | — | — | EP | disclosed |
| US-4774325-A | ANTILIPEMIC AGENTS | PIERREL SPA (IT) | 1988-09-27 | — | — | US | disclosed |
| EP-0175325-A2 | New 8-substituted nucleoside and purine derivatives, the process for the preparation thereof and the pharmaceutical compositions containing them | Pierrel S.p.A. (IT) | 1986-03-26 | — | — | EP | disclosed |