Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15842670 | 0.82 | ALDH1A1 (0.53) | HSD17B10ALDH1A1KDM4EGAACYP3A4 | |
| SCHEMBL5472418 | 0.82 | HSD17B10 (0.54) | HSD17B10ALDH1A1KDM4EGAACYP3A4 | |
| SCHEMBL6810404 | 0.77 | GAA (0.69) | HSD17B10ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL27947283 | 0.77 | KDM4E (0.62) | HSD17B10ALDH1A1KDM4EGAACYP3A4 | |
| SCHEMBL669540 | 0.77 | KDM4E (0.62) | HSD17B10ALDH1A1KDM4ECYP3A4MAPT | |
| SCHEMBL22780916 | 0.77 | KDM4E (0.58) | HSD17B10ALDH1A1KDM4EGAACYP3A4 | |
| SCHEMBL28053823 | 0.74 | CA1 (0.51) | HSD17B10ALDH1A1KDM4EGAACYP3A4 | |
| SCHEMBL4970512 | 0.74 | CA1 (0.51) | HSD17B10ALDH1A1KDM4EGAACYP3A4 | |
| SCHEMBL6810405 | 0.73 | GAA (0.69) | HSD17B10ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL669541 | 0.73 | KDM4E (0.58) | HSD17B10ALDH1A1KDM4EGAACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0185319-B1 | FLUORO COUMARINS AS ANTILYMPHOEDEMA AGENTS | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1989-09-06 | — | — | EP | disclosed |
| US-4749798-A | ANTIINFLAMMATORY, ANTISWELLING | BOEHRINGER BIOCHEMIA ROBIN SPA (IT) | 1988-06-07 | — | — | US | disclosed |
| EP-0185319-A2 | Fluoro coumarins as antilymphoedema agents | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1986-06-25 | — | — | EP | disclosed |