Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 7/20 | 0.67 |
| ▸ | AR | P10275 | 6/20 | 0.67 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nomegestrol SCHEMBL19760878 | 0.84 | LMNA (0.80) | PGRARNR3C1PDE4DCYP3A4 | |
| Nomegestrol SCHEMBL139763 | 0.84 | LMNA (0.80) | PGRARNR3C1PDE4DCYP3A4 | |
| Nomegestrol SCHEMBL6415665 | 0.83 | LMNA (0.79) | PGRARNR3C1PDE4DCYP3A4 | |
| Nomegestrol SCHEMBL37518 | 0.82 | LMNA (0.77) | PGRARNR3C1PDE4DCYP3A4 | |
| SCHEMBL10605148 | 0.80 | CYP3A4 (0.48) | PGRARNR3C1PDE4DCYP3A4 | |
| Nomegestrol Acetate SCHEMBL8817628 | 0.80 | PGR (1.00) | PGRARNR3C1PDE4DCYP3A4 | |
| Nomegestrol Acetate SCHEMBL19760877 | 0.80 | PGR (1.00) | PGRARNR3C1PDE4DCYP3A4 | |
| Nomegestrol Acetate SCHEMBL37517 | 0.80 | PGR (1.00) | PGRARNR3C1PDE4DCYP3A4 | |
| Nomegestrol SCHEMBL27486762 | 0.80 | LMNA (0.76) | PGRARNR3C1PDE4DCYP3A4 | |
| SCHEMBL10603271 | 0.79 | PGR (0.70) | PGRARNR3C1PDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0152429-B1 | PROGESTATIONALLY ACTIVE STEROIDS | RESEARCH TRIANGLE INSTITUTE (US) | 1989-10-11 | — | — | EP | disclosed |
| EP-0152429-A4 | PROGESTATIONALLY ACTIVE STEROIDS. | RES TRIANGLE INST (US) | 1985-12-05 | — | — | EP | disclosed |
| EP-0152429-A1 | PROGESTATIONALLY ACTIVE STEROIDS. | RES TRIANGLE INST (US) | 1985-08-28 | — | — | EP | disclosed |
| US-4512986-A | FERTILITY CONTROL | RESEARCH TRIANGLE INSTITUTE (US) | 1985-04-23 | — | — | US | disclosed |
| WO-1985000609-A1 | PROGESTATIONALLY ACTIVE STEROIDS | RESEARCH TRIANGLE INSTITUTE (US) | 1985-02-14 | — | — | WO | disclosed |