Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR3A | P46098 | 4/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.43 |
| ▸ | HTR3B | O95264 | 3/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10611520 | 0.79 | ACHE (0.44) | ACHEBCHECHRM1EPHX2CYP1A2 | |
| SCHEMBL10482089 | 0.78 | MAPT (0.44) | ACHEBCHECHRM1EPHX2ALDH1A1 | |
| SCHEMBL10610084 | 0.78 | SMN1; SMN2 (0.41) | ACHEBCHECHRM1EPHX2ALDH1A1 | |
| SCHEMBL10608330 | 0.77 | GPR39 (0.41) | KMT2AACHEBCHECHRM1EPHX2 | |
| SCHEMBL10481965 | 0.76 | MAPT (0.53) | KMT2AACHEBCHECHRM1EPHX2 | |
| SCHEMBL10575185 | 0.74 | ACHE (0.49) | ACHEBCHECHRM1EPHX2KDM4E | |
| SCHEMBL10481923 | 0.73 | MAPT (0.45) | KMT2AACHEBCHECHRM1EPHX2 | |
| SCHEMBL10481993 | 0.73 | MAPT (0.45) | KMT2AACHEBCHECHRM1EPHX2 | |
| SCHEMBL10481954 | 0.72 | MAPT (0.46) | KMT2ATP53MAPTSMN1; SMN2 | |
| SCHEMBL10572012 | 0.69 | ACHE (0.43) | KMT2AACHEBCHECHRM1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4751305-A | ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-06-14 | — | — | US | claimed |
| US-4751305-A | ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-06-14 | — | — | US | disclosed |
| US-4748246-A | INTERLEUKIN ANTAGONISTS, ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-05-31 | — | — | US | disclosed |