Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 10/20 | 0.44 |
| ▸ | BCHE | P06276 | 7/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10610084 | 0.81 | SMN1; SMN2 (0.41) | ACHEBCHECHRM1EPHX2CYP1A2 | |
| SCHEMBL10481965 | 0.80 | MAPT (0.53) | ACHEBCHECHRM1EPHX2TP53 | |
| SCHEMBL10608343 | 0.79 | KMT2A (0.45) | ACHEBCHECHRM1EPHX2CYP1A2 | |
| SCHEMBL10482089 | 0.79 | MAPT (0.44) | ACHEBCHECHRM1EPHX2CYP3A4 | |
| SCHEMBL10575185 | 0.78 | ACHE (0.49) | ACHEBCHECHRM1EPHX2CYP1A2 | |
| SCHEMBL10481923 | 0.77 | MAPT (0.45) | ACHEBCHECHRM1EPHX2TP53 | |
| SCHEMBL10481993 | 0.77 | MAPT (0.45) | ACHEBCHECHRM1EPHX2TP53 | |
| SCHEMBL10608330 | 0.76 | GPR39 (0.41) | ACHEBCHECHRM1EPHX2 | |
| SCHEMBL10481954 | 0.75 | MAPT (0.46) | TP53MAPTSMN1; SMN2 | |
| SCHEMBL10572012 | 0.72 | ACHE (0.43) | ACHEBCHECHRM1EPHX2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4751305-A | ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-06-14 | — | — | US | claimed |
| US-4751305-A | ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-06-14 | — | — | US | disclosed |
| US-4748246-A | INTERLEUKIN ANTAGONISTS, ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-05-31 | — | — | US | disclosed |