SCHEMBL1060985

SCHEMBL1060985

C=CCCCCCCCC=CCCCCCC=CCCCC

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.75
ALDH1A1 P00352 1/20 0.74
FAAH O00519 2/20 0.52
TRPV1 Q8NER1 1/20 0.52
F7 P08709 1/20 0.50
F3 P13726 1/20 0.50
GMNN O75496 1/20 0.45
USP2 O75604 1/20 0.45
LMNA P02545 1/20 0.45
CYP1A2 P05177 1/20 0.45
POLB P06746 1/20 0.45
MAPT P10636 1/20 0.45
CYP2C9 P11712 1/20 0.45
ALOX15 P16050 1/20 0.45
APEX1 P27695 1/20 0.45
CYP2C19 P33261 1/20 0.45
RECQL P46063 1/20 0.45
BLM P54132 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
HSD17B10 Q99714 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17651480 1.00 TSHR (0.75) TSHRALDH1A1FAAHTRPV1F7
SCHEMBL10628419 1.00 TSHR (0.75) TSHRALDH1A1FAAHTRPV1F7
SCHEMBL6720067 1.00 TSHR (0.75) TSHRALDH1A1FAAHTRPV1F7
SCHEMBL3514428 1.00 TSHR (0.75) TSHRALDH1A1FAAHTRPV1F7
SCHEMBL6432087 1.00 TSHR (0.75) TSHRALDH1A1FAAHTRPV1F7
SCHEMBL7099079 1.00 TSHR (0.75) TSHRALDH1A1FAAHTRPV1F7
SCHEMBL6480109 1.00 TSHR (0.75) TSHRALDH1A1FAAHTRPV1F7
SCHEMBL5489696 1.00 TSHR (0.75) TSHRALDH1A1FAAHTRPV1F7
SCHEMBL6272868 1.00 TSHR (0.75) TSHRALDH1A1FAAHTRPV1F7
SCHEMBL28211546 1.00 TSHR (0.75) TSHRALDH1A1FAAHTRPV1F7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2216318-B1 Resolvins: Biotemplates for therapeutic interventions BRIGHAM & WOMENS HOSPITAL (US) 2018-10-10 EP disclosed
US-9364454-B2 Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2016-06-14 US disclosed
US-8933270-B2 Use of docasatrienes, resolvins, and their stable analogs in the treatment of airway diseases and asthma THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2015-01-13 US disclosed
US-20140179630-A1 USE OF DOCASATRIENES, RESOLVINS, AND THEIR STABLE ANALOGS IN THE TREATMENT OF AIRWAY DISEASES AND ASTHMA THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2014-06-26 US disclosed
US-8569542-B2 Use of docosatrienes, resolvins, and their stable analogs in the treatment of airway diseases and asthma THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2013-10-29 US disclosed
US-20130217771-A1 RESOLVINS: BIOEMPLATES FOR NOVEL THERAPEUTIC INTERVENTIONS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2013-08-22 US disclosed
US-20130150446-A1 ANTI-INFLAMMATORY ACTIONS OF NEUROPROTECTIN D1/PROTECTIN D1 AND ITS NATURAL STEREOISOMERS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2013-06-13 US disclosed
US-20120264713-A1 USE OF DOCOSATRIENES, RESOLVINS, AND THEIR STABLE ANALOGS IN THE TREATMENT OF AIRWAY DISEASES AND ASTHMA THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2012-10-18 US disclosed
US-8273792-B2 Anti-inflammatory actions of neuroprotectin D1/protectin D1 and it's natural stereoisomers THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2012-09-25 US disclosed
US-7872152-B2 Di- and tri-hydroxy derivatives of eicosapentaenoic acid and docosahexaenoic acid coadministered with a cyclooxygenase-2 inhibitor; antiinflammatory agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2011-01-18 US disclosed
US-20090156673-A1 ANTI-INFLAMMATORY ACTIONS OF NEUROPROTECTIN D1/PROTECTIN D1 AND IT'S NATURAL STEREOISOMERS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. CORPORATE SPONSORED RESEARCH & LICENSING (US) 2009-06-18 US disclosed
US-20080096961-A1 Di- and tri-hydroxy derivatives of eicosapentaenoic acid and docosahexaenoic acid coadministered with a cyclooxygenase-2 inhibitor; antiinflammatory agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2008-04-24 US disclosed
WO-2007041440-A2 ANTI-INFLAMMATORY ACTIONS OF NEUROPROTECTIN D1/PROTECTIN D1 AND ITS NATURAL STEREOISOMERS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2007-04-12 WO disclosed
EP-1725228-A2 USE OF DOCOSATRIENES, RESOLVINS AND THEIR STABLE ANALOGS IN THE TREATMENT OF AIRWAY DISEASES AND ASTHMA THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2006-11-29 EP disclosed
US-20050261255-A1 Di- and tri-hydroxy derivatives of eicosapentaenoic acid and docosahexaenoic acid coadministered with a cyclooxygenase-2 inhibitor; antiinflammatory agents NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2005-11-24 US disclosed
WO-2005089744-A2 USE OF DOCOSATRIENES, RESOLVINS AND THEIR STABLE ANALOGS IN THE TREATMENT OF AIRWAY DISEASES AND ASTHMA THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2005-09-29 WO disclosed
EP-1537067-A2 RESOLVINS: BIOTEMPLATES FOR THERAPEUTIC INTERVENTIONS BRIGHAM AND WOMEN'S HOSPITAL (US) 2005-06-08 EP disclosed
WO-2004014835-A9 RESOLVINS: BIOTEMPLATES FOR THERAPEUTIC INTERVENTIONS BRIGHAM & WOMENS HOSPITAL (US) 2004-07-08 WO disclosed
US-20040116408-A1 Resolvins: biotemplates for novel therapeutic interventions NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2004-06-17 US disclosed
WO-2004014835-A2 RESOLVINS: BIOTEMPLATES FOR THERAPEUTIC INTERVENTIONS BRIGHAM AND WOMEN'S HOSPITAL (US) 2004-02-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130217771-A1 RESOLVINS: BIOEMPLATES FOR NOVEL THERAPEUTIC INTERVENTIONS PTGES3, ALOX5, PTGES2 TSHR 4768/4885ALDH1A1 799/4885FAAH 84/4885
US-20120264713-A1 USE OF DOCOSATRIENES, RESOLVINS, AND THEIR STABLE ANALOGS IN THE TREATMENT OF AIRWAY DISEASES AND ASTHMA PTGER3, PTGER2, ALOX5 TSHR 4316/4885ALDH1A1 911/4885FAAH 114/4885
US-20140179630-A1 USE OF DOCASATRIENES, RESOLVINS, AND THEIR STABLE ANALOGS IN THE TREATMENT OF AIRWAY DISEASES AND ASTHMA PTGER3, PTGER2, ALOX5 TSHR 4293/4885ALDH1A1 922/4885FAAH 116/4885
US-20080096961-A1 Di- and tri-hydroxy derivatives of eicosapentaenoic acid and docosahexaenoic acid coadministered with a cyclooxygenase-2 inhibitor; antiinflammatory agents ALOX5, PTGES2, PTGER3 TSHR 4178/4885ALDH1A1 726/4885FAAH 75/4885
US-20050261255-A1 Di- and tri-hydroxy derivatives of eicosapentaenoic acid and docosahexaenoic acid coadministered with a cyclooxygenase-2 inhibitor; antiinflammatory agents ALOX5, PTGES2, PTGES3 TSHR 4343/4885ALDH1A1 768/4885FAAH 78/4885
US-20130150446-A1 ANTI-INFLAMMATORY ACTIONS OF NEUROPROTECTIN D1/PROTECTIN D1 AND ITS NATURAL STEREOISOMERS PTGER1, PTGES, PTGS1 TSHR 3888/4885ALDH1A1 1172/4885FAAH 81/4885
US-20090156673-A1 ANTI-INFLAMMATORY ACTIONS OF NEUROPROTECTIN D1/PROTECTIN D1 AND IT'S NATURAL STEREOISOMERS ALOX15, ALOX12, ALOX15B TSHR 3515/4885ALDH1A1 302/4885FAAH 170/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.