Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | GRM3 | Q14832 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10610075 | 1.00 | GBA2 (0.49) | GBA2SMN1; SMN2POLBLMNANPC1 | |
| SCHEMBL4599962 | 0.94 | SMN1; SMN2 (0.49) | GBA2SMN1; SMN2POLBLMNANPC1 | |
| SCHEMBL29812927 | 0.94 | SMN1; SMN2 (0.49) | GBA2SMN1; SMN2POLBLMNANPC1 | |
| SCHEMBL29813031 | 0.90 | SMN1; SMN2 (0.48) | GBA2SMN1; SMN2POLBLMNANPC1 | |
| SCHEMBL5724467 | 0.86 | LMNA (0.51) | GBA2SMN1; SMN2POLBLMNANR1H4 | |
| SCHEMBL9285131 | 0.86 | LMNA (0.51) | GBA2SMN1; SMN2POLBLMNANR1H4 | |
| SCHEMBL8324568 | 0.85 | POLB (0.50) | GBA2SMN1; SMN2POLBLMNANR1H4 | |
| SCHEMBL5629746 | 0.84 | EPHX2 (0.49) | SMN1; SMN2POLBNPC1RAB9ANR1H4 | |
| SCHEMBL30678922 | 0.84 | SMN1; SMN2 (0.47) | GBA2SMN1; SMN2POLBLMNANPC1 | |
| SCHEMBL9760333 | 0.83 | LPAR3 (0.42) | GBA2SMN1; SMN2POLBLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0213082-B1 | SUBSTITUTED HYDROXY-HETEROCYCLYL-ALKOXY PHOSPHINYLOXY TRIALKYLAMINIUM HYDROXIDE INNER SALT OXIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SANDOZ AG (CH) | 1989-10-18 | — | — | EP | disclosed |
| US-4749696-A | ANTICARCINOGENIC AGENT | SANDOZ PHARM. CORP. (US) | 1988-06-07 | — | — | US | disclosed |