Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10634597 | 0.79 | NPC1 (0.47) | MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4859201 | 0.72 | HTT (0.56) | HTTMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL5324181 | 0.70 | HTT (0.74) | HTTMEN1KMT2AHSD17B10ALDH1A1 | |
| SCHEMBL8570609 | 0.70 | MAPT (0.62) | HTTMAPTHSD17B10ALDH1A1TSHR | |
| SCHEMBL17401408 | 0.69 | ENPP2 (0.80) | — | |
| SCHEMBL13501425 | 0.69 | HSD17B10 (0.60) | HTTMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL31751244 | 0.69 | KDM4E (0.43) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11277508 | 0.68 | KDM4E (0.58) | HTTMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL5282599 | 0.68 | HTT (0.64) | HTTMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL15656249 | 0.68 | ALDH1A1 (0.77) | HTTMEN1KMT2AMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4767858-A | Anti-arthritic pyrazolo-triazine derivatives | BIOMEASURE, INCORPORATED (US) | 1988-08-30 | — | — | US | claimed |
| EP-0207651-A2 | Anti-inflammatory 7-phenyl pyrazolo-[1,5A]-1,3,5-triazine derivatives | BIOMEASURE, INC. (US) | 1987-01-07 | — | — | EP | claimed |
| US-4767858-A | Anti-arthritic pyrazolo-triazine derivatives | BIOMEASURE, INCORPORATED (US) | 1988-08-30 | — | — | US | disclosed |
| US-4734414-A | Anti-inflammatory and anti-arthritic pyrazolo-[1,5-a]-1,3,5-triazine derivatives, compositions, and method of use therefor | BIOMEASURE, INC. (US) | 1988-03-29 | — | — | US | disclosed |
| EP-0207651-A2 | Anti-inflammatory 7-phenyl pyrazolo-[1,5A]-1,3,5-triazine derivatives | BIOMEASURE, INC. (US) | 1987-01-07 | — | — | EP | disclosed |