Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.73 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.73 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.73 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10638586 | 0.85 | SLC6A3 (0.76) | SLC6A3SLC6A2SLC6A4SIGMAR1LMNA | |
| SCHEMBL27747290 | 0.83 | HTR1A (0.63) | SLC6A3SLC6A2SLC6A4SIGMAR1LMNA | |
| SCHEMBL4575709 | 0.77 | DRD2 (0.44) | SLC6A3SLC6A2SLC6A4SIGMAR1MEN1 | |
| SCHEMBL597494 | 0.77 | SLC6A3 (0.83) | SLC6A3SLC6A2SLC6A4SIGMAR1LMNA | |
| SCHEMBL8647649 | 0.76 | LMNA (0.83) | SLC6A3SLC6A2SLC6A4SIGMAR1LMNA | |
| SCHEMBL8642037 | 0.76 | LMNA (0.78) | SLC6A3SLC6A2SLC6A4SIGMAR1LMNA | |
| SCHEMBL8645362 | 0.75 | LMNA (0.81) | SLC6A3SLC6A2SLC6A4SIGMAR1LMNA | |
| SCHEMBL10551886 | 0.75 | SIGMAR1 (0.73) | SLC6A3SLC6A2SLC6A4SIGMAR1LMNA | |
| SCHEMBL9430393 | 0.75 | SIGMAR1 (0.73) | SLC6A3SLC6A2SLC6A4SIGMAR1LMNA | |
| SCHEMBL4576039 | 0.75 | DRD2 (0.45) | SIGMAR1CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0099148-B1 | PIPERAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | GIST-BROCADES N.V. (NL) | 1988-02-17 | — | — | EP | claimed |
| EP-0099148-B1 | PIPERAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | GIST-BROCADES N.V. (NL) | 1988-02-17 | — | — | EP | disclosed |