Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | HRH1 | P35367 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.56 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10627 | 0.89 | EPHX2 (0.66) | LMNAHRH3KCNH2MAPTALDH1A1 | |
| SCHEMBL14006288 | 0.88 | LMNA (0.70) | LMNATSHRHRH3KCNH2MAPT | |
| SCHEMBL14006202 | 0.88 | LMNA (0.70) | LMNATSHRHRH3KCNH2MAPT | |
| SCHEMBL14006223 | 0.87 | LMNA (0.68) | LMNATSHRHRH3KCNH2MAPT | |
| SCHEMBL10378 | 0.83 | LIPE (0.58) | LMNAMAPTALDH1A1KMT2ATHRB | |
| SCHEMBL9390735 | 0.80 | L3MBTL1 (0.74) | MAPTALDH1A1CYP2D6MEN1CYP2C19 | |
| SCHEMBL14006284 | 0.79 | EPHX2 (0.60) | LMNATSHRMAPTALDH1A1HRH1 | |
| SCHEMBL4094339 | 0.78 | HRH3 (1.00) | HRH3KCNH2HRH1HRH2 | |
| SCHEMBL12050645 | 0.78 | HRH3 (1.00) | HRH3KCNH2HRH1HRH2 | |
| SCHEMBL491776 | 0.78 | HRH2 (0.83) | LMNATSHRHRH3KCNH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488489-A2 | C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | Pfizer Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011045703-A2 | C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 2011-04-21 | — | — | WO | disclosed |