Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.43 |
| ▸ | HTR3B | O95264 | 2/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29636402 | 0.78 | TRPV4 (0.55) | TRPV4ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL2127233 | 0.78 | TRPV4 (0.55) | TRPV4ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL339512 | 0.77 | CSNK2A1 (0.43) | HPGDPOLBTSHR | |
| SCHEMBL339511 | 0.77 | CSNK2A1 (0.43) | HPGDPOLBTSHR | |
| SCHEMBL2811536 | 0.76 | CA2 (0.41) | ALDH1A1POLBMEN1KMT2ATSHR | |
| SCHEMBL29687129 | 0.76 | TTR (0.62) | TRPV4ALDH1A1KDM4EHPGDPOLB | |
| SCHEMBL7699644 | 0.76 | ALDH1A1 (0.56) | TRPV4ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL196490 | 0.76 | TTR (0.62) | TRPV4ALDH1A1KDM4EHPGDPOLB | |
| SCHEMBL28298273 | 0.76 | TRPV4 (0.53) | TRPV4ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL23565733 | 0.76 | KMT2A (0.61) | ALDH1A1HPGDPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0146893-B1 | BENZOTHIAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM, AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-08-24 | — | — | EP | disclosed |