Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9827001 | 0.82 | AOC3 (0.37) | SLC6A2SLC6A4SLC6A3CYP3A4 | |
| SCHEMBL4464586 | 0.81 | TDP1 (0.44) | TDP1ALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL9826255 | 0.79 | PKM (0.43) | MAPTTDP1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3901257 | 0.78 | ALDH1A1 (0.35) | ALDH1A1 | |
| SCHEMBL9721607 | 0.70 | AOC3 (0.50) | ALDH1A1 | |
| SCHEMBL18531113 | 0.69 | TDP1 (0.43) | TDP1ALDH1A1 | |
| SCHEMBL20125070 | 0.69 | TDP1 (0.43) | TDP1ALDH1A1 | |
| SCHEMBL2476049 | 0.69 | ALDH1A1 (0.37) | MAPTTDP1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28893556 | 0.69 | SLC6A4 (0.39) | HTR2ASLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL8465860 | 0.69 | HTR2A (0.38) | HTR2ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4758573-A | Heterocyclic group-containing compounds | G. D. SEARLE & CO. (US) | 1988-07-19 | — | — | US | disclosed |
| EP-0105575-B1 | 1-(1H-IMIDAZOLYL), 1-N-MORPHOLINYL AND PYRIDYL COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | G.D. Searle & Co. (US) | 1987-03-04 | — | — | EP | disclosed |
| US-4579862-A | TREATMENT OF CEREBROVASCULAR DISEACE, ISCHEMIA, DIABETES, ANGINA, MYOCARDIAL INFARCTION | G. D. SEARLE & CO. (US) | 1986-04-01 | — | — | US | disclosed |
| EP-0105575-A1 | 1-(1H-imidazolyl), 1-N-morpholinyl and pyridyl compounds, their preparation and pharmaceutical compositions containing them | G.D. Searle & Co. (US) | 1984-04-18 | — | — | EP | disclosed |