Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL334107 | 0.81 | PKM (0.37) | PKMAOC3LMNACYP1A2CYP2D6 | |
| SCHEMBL9827001 | 0.79 | AOC3 (0.37) | AOC3CYP1A2CYP2D6CYP2C19SLC6A2 | |
| SCHEMBL10643254 | 0.79 | MAPT (0.37) | TSHRALDH1A1TDP1SLC6A2SLC6A4 | |
| SCHEMBL4464586 | 0.79 | TDP1 (0.44) | TSHRALDH1A1TDP1KMT2ATP53 | |
| SCHEMBL3901257 | 0.75 | ALDH1A1 (0.35) | ALDH1A1 | |
| SCHEMBL10724656 | 0.75 | PKM (0.40) | PKMLMNACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9721607 | 0.75 | AOC3 (0.50) | AOC3ALDH1A1 | |
| SCHEMBL18531113 | 0.74 | TDP1 (0.43) | ALDH1A1TDP1KMT2AMEN1 | |
| SCHEMBL20125070 | 0.74 | TDP1 (0.43) | ALDH1A1TDP1KMT2AMEN1 | |
| SCHEMBL10724645 | 0.72 | KMT2A (0.45) | PKMCYP2D6CYP2C19MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150892-B1 | SUBSTITUTED ALKYLIDENE IMIDAZOLES | G.D. Searle & Co. (US) | 1991-04-24 | — | — | EP | disclosed |
| US-4837333-A | SELECTIVE INHIBITOR OF THROMBOXANE SYNTHETASE ENZYME | G. D. SEARLE & CO. (US) | 1989-06-06 | — | — | US | disclosed |
| US-4758573-A | Heterocyclic group-containing compounds | G. D. SEARLE & CO. (US) | 1988-07-19 | — | — | US | disclosed |
| EP-0105575-B1 | 1-(1H-IMIDAZOLYL), 1-N-MORPHOLINYL AND PYRIDYL COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | G.D. Searle & Co. (US) | 1987-03-04 | — | — | EP | disclosed |
| US-4636518-A | ANTICOAGULANTS | G. D. SEARLE & CO. (US) | 1987-01-13 | — | — | US | disclosed |
| EP-0062918-B1 | IMIDAZOLE DERIVATIVES | G.D. Searle & Co. (US) | 1986-07-30 | — | — | EP | disclosed |
| US-4579862-A | TREATMENT OF CEREBROVASCULAR DISEACE, ISCHEMIA, DIABETES, ANGINA, MYOCARDIAL INFARCTION | G. D. SEARLE & CO. (US) | 1986-04-01 | — | — | US | disclosed |
| US-4567189-A | Imidazole derivatives used in antithrombotic method | G. D. SEARLE & CO. (US) | 1986-01-28 | — | — | US | disclosed |
| EP-0150892-A2 | Substituted alkylidene imidazoles | G.D. Searle & Co. (US) | 1985-08-07 | — | — | EP | disclosed |
| EP-0105575-A1 | 1-(1H-imidazolyl), 1-N-morpholinyl and pyridyl compounds, their preparation and pharmaceutical compositions containing them | G.D. Searle & Co. (US) | 1984-04-18 | — | — | EP | disclosed |
| EP-0062918-A2 | Imidazole derivatives | G.D. Searle & Co. (US) | 1982-10-20 | — | — | EP | disclosed |