Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9047001 | 0.85 | KDM4E (0.45) | KDM4EALDH1A1MAPTNPSR1CYP1A2 | |
| SCHEMBL5526686 | 0.84 | NPSR1 (0.46) | KDM4EALDH1A1MAPTNPSR1NPY5R | |
| SCHEMBL10645428 | 0.81 | KDM4E (0.41) | KDM4EALDH1A1MAPTNPSR1CYP1A2 | |
| SCHEMBL4844072 | 0.77 | KDM4E (0.49) | KDM4EALDH1A1MAPTNPSR1CYP1A2 | |
| SCHEMBL14276601 | 0.74 | SLC9A1 (0.52) | KDM4EALDH1A1MAPTNPY5RSLC9A1 | |
| SCHEMBL5526688 | 0.73 | NPY5R (0.44) | KDM4EALDH1A1MAPTNPSR1CYP1A2 | |
| SCHEMBL2876016 | 0.70 | KDM4E (0.43) | KDM4EALDH1A1MAPTNPSR1CYP1A2 | |
| SCHEMBL2876019 | 0.70 | HSP90AA1 (0.50) | KDM4EALDH1A1MAPTNPSR1L3MBTL1 | |
| SCHEMBL11822002 | 0.70 | CYP1A2 (0.36) | KDM4EALDH1A1MAPTNPSR1CYP1A2 | |
| SCHEMBL10645477 | 0.70 | L3MBTL1 (0.39) | KDM4EALDH1A1MAPTNPSR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0121341-B1 | TRIAZOLO(4,3-C)PYRIMIDINES AND TRIAZOLO(1,5-C)PYRIMIDINES SUBSTITUTED BY NITROGEN-CONTAINING HETEROCYCLIC RINGS | RIKER LABORATORIES, INCORPORATED (US) | 1988-11-17 | — | — | EP | disclosed |
| US-4536579-A | BRONCHODILATING AGENTS | RIKER LABORATORIES, INC. (US) | 1985-08-20 | — | — | US | disclosed |
| US-4477450-A | BRONCHODILATORS | RIKER LABORATORIES, INC. (US) | 1984-10-16 | — | — | US | disclosed |
| EP-0121341-A1 | Triazolo(4,3-c)pyrimidines and triazolo(1,5-c)pyrimidines substituted by nitrogen-containing heterocyclic rings | RIKER LABORATORIES, INCORPORATED (US) | 1984-10-10 | — | — | EP | disclosed |