SCHEMBL10647488

SCHEMBL10647488

COc1ccc(-c2cc(C)no2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.64
CYP19A1 P11511 1/20 0.64
CYP2C9 P11712 1/20 0.64
CYP2C19 P33261 1/20 0.64
RAB9A P51151 8/20 0.61
NPC1 O15118 7/20 0.61
MAPT P10636 4/20 0.61
HPGD P15428 4/20 0.61
ALDH1A1 P00352 1/20 0.61
RECQL P46063 1/20 0.61
TP53 P04637 3/20 0.54
SMN1; SMN2 Q16637 3/20 0.54
HSD17B10 Q99714 1/20 0.52
KMT2A Q03164 3/20 0.51
HDAC3 O15379 1/20 0.51
HDAC4 P56524 1/20 0.51
HDAC1 Q13547 1/20 0.51
HDAC7 Q8WUI4 1/20 0.51
HDAC2 Q92769 1/20 0.51
HDAC10 Q969S8 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1181029 0.81 NPC1 (0.87) CYP2C9CYP2C19RAB9ANPC1MAPT
SCHEMBL16373541 0.81 ALDH1A1 (0.64) CYP1A2CYP2C19RAB9ANPC1MAPT
SCHEMBL2270503 0.80 NPC1 (0.59) CYP1A2CYP19A1CYP2C9CYP2C19RAB9A
SCHEMBL8375731 0.80 HPGD (0.64) RAB9ANPC1MAPTHPGDALDH1A1
SCHEMBL4104544 0.80 RAB9A (0.59) RAB9ANPC1MAPTHPGDALDH1A1
SCHEMBL17084390 0.80 NPC1 (0.77) CYP2C9CYP2C19RAB9ANPC1MAPT
SCHEMBL24307626 0.79 NPC1 (0.58) CYP1A2CYP19A1CYP2C9CYP2C19RAB9A
Ammonia Solution, Strong SCHEMBL28862474 0.79 NPC1 (0.58) CYP1A2CYP19A1CYP2C9CYP2C19RAB9A
SCHEMBL12180306 0.77 RAB9A (0.57) RAB9ANPC1MAPTHPGDALDH1A1
SCHEMBL4544353 0.77 NPC1 (0.56) RAB9ANPC1MAPTHPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200390100-A1 SUBSTITUTED N-HETEROCYCLYL- AND N-HETEROARYL-TETRAHYDROPYRIMIDINONES AND THE SALTS THEREOF, AND THE USE OF SAME AS HERBICIDAL ACTIVE SUBSTANCES BAYER AG (DE) 2020-12-17 US disclosed
WO-2018114596-A1 SUBSTITUTED HETEROARYL PYRROLONES AND SALTS THEREOF AND USE THEREOF AS HERBICIDAL ACTIVE SUBSTANCES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-06-28 WO disclosed
US-20170313713-A1 AMINOINDANE-, AMINOTETRAHYDRONAPHTHALENE- AND AMINOBENZOCYCLOBUTANE-DERIVED PRMT5-INHIBITORS CTXT PTY. LTD. (AU) 2017-11-02 US disclosed
US-20170298075-A1 TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS CTXT PTY. LTD. (AU) 2017-10-19 US disclosed
US-20170283407-A1 TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS CTXT PTY. LTD. (AU) 2017-10-05 US disclosed
US-9540361-B2 N-substituted azetidine derivatives MERCK SHARP & DOHME B.V. (NL) 2017-01-10 US disclosed
US-9365588-B2 Benzoxazines as modulators of ion channels VERTEX PHARMACEUTICALS INCORPORATED (US) 2016-06-14 US disclosed
US-20160130262-A1 N-SUBSTITUTED AZETIDINE DERIVATIVES MERCK SHARP & DOHME B.V. (NL) 2016-05-12 US disclosed
US-20140309220-A1 BENZOXAZINES AS MODULATORS OF ION CHANNELS VERTEX PHARMACEUTICALS INCORPORATED 2014-10-16 US disclosed
US-20140171427-A1 Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels VERTEX PHARMACEUTICALS INCORPORATED (US) 2014-06-19 US disclosed
US-20110306607-A1 HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS VERTEX PHARMACEUTICALS INCORPORATED (US) 2011-12-15 US disclosed
US-8013006-B2 Methods for treating hepatitis C PTC THERAPEUTICS, INC. (US) 2011-09-06 US disclosed
US-7973069-B2 Methods for treating hepatitis C PTC THERAPEUTICS, INC. (US) 2011-07-05 US disclosed
US-20100305100-A1 METHODS FOR TREATING HEPATITIS C PTC THERAPEUTICS, INC. (US) 2010-12-02 US disclosed
US-20100292187-A1 METHODS FOR TREATING HEPATITIS C PTC THERAPEUTICS, INC. (US) 2010-11-18 US disclosed
EP-0192931-B1 PROCESS FOR THE PREPARATION OF ISOXAZOLES FIRMENICH SA (CH) 1988-09-07 EP disclosed
US-4670109-A ANODIC OXIDATION OF ALPHA-BETA UNSATURATED OXIMES FIRMENICH SA (CH) 1987-06-02 US disclosed
EP-0192931-A1 Process for the preparation of isoxazoles FIRMENICH SA (CH) 1986-09-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170313713-A1 AMINOINDANE-, AMINOTETRAHYDRONAPHTHALENE- AND AMINOBENZOCYCLOBUTANE-DERIVED PRMT5-INHIBITORS PRMT5, PRMT1, PRMT3 CYP1A2 820/4885CYP19A1 2114/4885CYP2C9 1866/4885
US-20200390100-A1 SUBSTITUTED N-HETEROCYCLYL- AND N-HETEROARYL-TETRAHYDROPYRIMIDINONES AND THE SALTS THEREOF, AND THE USE OF SAME AS HERBICIDAL ACTIVE SUBSTANCES DDT, NOTUM, AGPS CYP1A2 26/4885CYP19A1 828/4885CYP2C9 18/4885
US-20140171427-A1 Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels KCNJ2, TRPV1, KCNJ1 CYP1A2 2162/4885CYP19A1 2862/4885CYP2C9 2845/4885
US-20170298075-A1 TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS PRMT5, PRMT1, PRMT3 CYP1A2 1959/4885CYP19A1 3640/4885CYP2C9 2587/4885
US-20110306607-A1 HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS KCNJ2, TRPV1, KCNJ1 CYP1A2 2162/4885CYP19A1 2862/4885CYP2C9 2845/4885
US-20100292187-A1 METHODS FOR TREATING HEPATITIS C HAVCR2, EIF2AK2, MAVS CYP1A2 3179/4885CYP19A1 4051/4885CYP2C9 3639/4885
US-20100305100-A1 METHODS FOR TREATING HEPATITIS C HAVCR2, EIF2AK2, MAVS CYP1A2 3179/4885CYP19A1 4051/4885CYP2C9 3639/4885
US-20170283407-A1 TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS PRMT5, PRMT3, PRMT1 CYP1A2 1990/4885CYP19A1 3457/4885CYP2C9 2640/4885
US-20140309220-A1 BENZOXAZINES AS MODULATORS OF ION CHANNELS KCNJ1, KCNJ2, KCNJ11 CYP1A2 1118/4885CYP19A1 1954/4885CYP2C9 1652/4885
US-20160130262-A1 N-SUBSTITUTED AZETIDINE DERIVATIVES ESR2, ESR1, GPER1 CYP1A2 799/4885CYP19A1 6/4885CYP2C9 1685/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.