Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.38 |
| ▸ | GRM6 | O15303 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 6/20 | 0.36 |
| ▸ | F13A1 | P00488 | 1/20 | 0.36 |
| ▸ | TGM1 | P22735 | 1/20 | 0.36 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 5/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | TEC | P42680 | 1/20 | 0.35 |
| ▸ | TXK | P42681 | 1/20 | 0.35 |
| ▸ | BMX | P51813 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6131099 | 0.82 | MAPK3 (0.40) | KDM4EALDH1A1GLAGAAMAPT | |
| SCHEMBL2730411 | 0.78 | GRM6 (0.49) | KDM4EALDH1A1GLAGAAMAPT | |
| SCHEMBL16680460 | 0.75 | THRB (0.40) | KDM4EALDH1A1GLAGAAMAPT | |
| SCHEMBL1064806 | 0.75 | TGM2 (0.46) | ALDH1A1MAPK3TGM2F13A1TGM1 | |
| SCHEMBL29352309 | 0.75 | TGM2 (0.46) | ALDH1A1MAPK3TGM2F13A1TGM1 | |
| SCHEMBL16096123 | 0.74 | TGM2 (0.47) | TGM2F13A1TGM1BTKJAK3 | |
| SCHEMBL1064513 | 0.73 | HDAC1 (0.45) | KDM4EALDH1A1GLAMAPT | |
| SCHEMBL2316517 | 0.73 | TGM2 (0.55) | TGM2PTPN1PTPN11 | |
| SCHEMBL29416535 | 0.73 | TGM2 (0.55) | TGM2PTPN1PTPN11 | |
| SCHEMBL2718238 | 0.72 | CA12 (0.48) | KDM4EALDH1A1GLAGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1578663-B | Histone deacetylase inhibitors | METHYLGENE INC | 2011-05-25 | — | — | CN | disclosed |
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| CN-101851173-A | Inhibitors of histone deacetylase | METHYLGENE INC | 2010-10-06 | — | — | CN | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |
| CN-100540547-C | Inhibitors of histone deacetylase | METHYLGENE INC (CA) | 2009-09-16 | — | — | CN | disclosed |
| CN-1723207-A | Histone deacetylase inhibitors | METHYLGENE INC (CA) | 2006-01-18 | — | — | CN | disclosed |
| US-6897220-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2005-05-24 | — | — | US | disclosed |
| CN-1578663-A | Histone deacetylase inhibitors | METHYLGENE INC (CA) | 2005-02-09 | — | — | CN | disclosed |
| US-20040142953-A1 | Inhibitors of histone deacetylase | METHYLGENE, INC. | 2004-07-22 | — | — | US | disclosed |
| US-20040106599-A1 | Inhibitors of histone deacetylase | 92229129 QUEBEC INC. (CA) | 2004-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106599-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC5, HDAC3 | KDM4E 123/4885ALDH1A1 796/4885GLA 402/4885 |
| US-20040142953-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC5, HDAC3 | KDM4E 123/4885ALDH1A1 796/4885GLA 402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.