Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HMOX1 | P09601 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280421 | 0.87 | PDE3B (0.61) | PDE3BPDE3ACYP19A1CYP11B1 | |
| SCHEMBL7290394 | 0.81 | TBXAS1 (0.58) | PDE3BPDE3AHRH3KMT2ATBXAS1 | |
| SCHEMBL11115116 | 0.78 | PDE3B (0.44) | PDE3BPDE3AMAPTKMT2ACYP19A1 | |
| SCHEMBL7280366 | 0.74 | PDE3B (1.00) | PDE3BPDE3AMAPTKMT2ALMNA | |
| SCHEMBL10651613 | 0.73 | PDE3B (0.43) | PDE3BPDE3AMAPTCYP19A1TBXAS1 | |
| SCHEMBL10353474 | 0.73 | MAPT (0.80) | PDE3BPDE3AMAPTHRH3KMT2A | |
| SCHEMBL1640658 | 0.73 | MAPT (0.66) | PDE3BPDE3AMAPTHRH3KMT2A | |
| SCHEMBL7302713 | 0.73 | MAPT (0.66) | PDE3BPDE3AMAPTHRH3KMT2A | |
| SCHEMBL10649218 | 0.72 | TBXAS1 (0.42) | PDE3BPDE3ATBXAS1HMOX1CYP11B1 | |
| Hydrochloric Acid SCHEMBL11371114 | 0.72 | CYP11B1 (0.69) | MAPTKMT2ACYP19A1TBXAS1HMOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0075436-A1 | Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted)phenyl-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1983-03-30 | — | — | EP | claimed |