Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 4/20 | 0.48 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10511510 | 0.86 | ALDH1A1 (0.56) | FPR2HSD17B3ALDH1A1PKMRAD52 | |
| SCHEMBL10650608 | 0.84 | NPSR1 (0.50) | FPR2HSD17B3ALDH1A1PKMRAD52 | |
| SCHEMBL10653259 | 0.83 | MEN1 (0.40) | HSD17B3ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL10511618 | 0.81 | LMNA (0.45) | HSD17B3ALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL10507726 | 0.78 | KCNN4 (0.39) | FPR2HSD17B3MEN1KMT2AGAA | |
| SCHEMBL10507993 | 0.78 | HSD17B10 (0.44) | HSD17B3ALDH1A1HPGDNPSR1MEN1 | |
| SCHEMBL4971828 | 0.77 | NPSR1 (0.48) | HSD17B3ALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL30808641 | 0.77 | ALDH1A1 (0.47) | FPR2HSD17B3ALDH1A1PKMRAD52 | |
| SCHEMBL11037157 | 0.76 | FPR2 (0.45) | FPR2HSD17B3ALDH1A1PKMRAD52 | |
| SCHEMBL11037153 | 0.76 | FPR2 (0.45) | FPR2HSD17B3ALDH1A1PKMRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0162776-B1 | HETEROCYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS USEFUL AS ALDOSE REDUCTASE INHIBITORS CONTAINING THEM | LABORATOIRES UPSA (FR) | 1989-04-19 | — | — | EP | disclosed |
| US-4755509-A | Heterocyclic aldose reductase inhibitors and methods of using them | Carbipem (FR) | 1988-07-05 | — | — | US | disclosed |
| EP-0162776-A2 | Heterocyclic derivatives, process for their preparation and medicaments useful as aldose reductase inhibitors containing them | LABORATOIRES UPSA (FR) | 1985-11-27 | — | — | EP | disclosed |