Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 13/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10655291 | 0.99 | OPRM1 (0.41) | OPRM1MEN1KMT2ASIGMAR1SLC22A1 | |
| SCHEMBL11015572 | 0.89 | OPRM1 (0.43) | OPRM1MEN1KMT2ACASP1CASP7 | |
| SCHEMBL10656089 | 0.89 | CASP1 (0.40) | OPRM1MEN1KMT2ADRD2DRD4 | |
| SCHEMBL11015645 | 0.89 | OPRM1 (0.41) | OPRM1MEN1KMT2ADRD2DRD4 | |
| Hydrochloric Acid SCHEMBL10652939 | 0.88 | OPRM1 (0.42) | OPRM1MEN1KMT2ACASP1CASP7 | |
| Hydrochloric Acid SCHEMBL10656009 | 0.88 | OPRM1 (0.40) | OPRM1MEN1KMT2ADRD2DRD4 | |
| SCHEMBL10652472 | 0.86 | KMT2A (0.37) | OPRM1MEN1KMT2ADRD2DRD4 | |
| Hydrochloric Acid SCHEMBL10653899 | 0.86 | MEN1 (0.44) | OPRM1MEN1KMT2ACHRM3SLC6A3 | |
| SCHEMBL10653284 | 0.85 | TRPV1 (0.37) | OPRM1MEN1KMT2ADRD2DRD3 | |
| SCHEMBL10656530 | 0.85 | KMT2A (0.39) | OPRM1MEN1KMT2AHPGDCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0141968-B1 | PYRROLYLAMINOPIPERIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-05-18 | — | — | EP | claimed |
| US-4452803-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1984-06-05 | — | — | US | claimed |
| EP-0141968-B1 | PYRROLYLAMINOPIPERIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-05-18 | — | — | EP | disclosed |
| US-4546105-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-10-08 | — | — | US | disclosed |
| EP-0141968-A1 | Pyrrolylaminopiperidines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-05-22 | — | — | EP | disclosed |
| US-4452803-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1984-06-05 | — | — | US | disclosed |