Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | KIT | P10721 | 9/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10567524 | 0.85 | ALDH1A1 (0.62) | PDE4APDE4BPDE4CPDE4DKIT | |
| SCHEMBL10565550 | 0.74 | KIT (0.44) | PDE4APDE4BPDE4CPDE4DKIT | |
| SCHEMBL10567559 | 0.70 | KDM4E (0.54) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL3343223 | 0.69 | NPC1 (0.49) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL9529073 | 0.68 | L3MBTL1 (0.55) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL28705161 | 0.67 | MAPT (0.50) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL11017001 | 0.67 | KDM4E (0.50) | KITDYRK1AALDH1A1L3MBTL1KDM4E | |
| SCHEMBL17446135 | 0.67 | NPC1 (0.55) | KITDYRK1AALDH1A1KDM4EMAPT | |
| SCHEMBL4329785 | 0.67 | KDR (0.70) | KITDYRK1AKDR | |
| SCHEMBL8840880 | 0.67 | PDE4A (0.67) | PDE4AALDH1A1LMNAL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0123402-B1 | PYRIMIDINE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-09-07 | — | — | EP | disclosed |