Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 7/20 | 0.45 |
| ▸ | CES2 | O00748 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3730123 | 0.80 | CES2 (0.54) | L3MBTL1CES1CES2LMNAKMT2A | |
| SCHEMBL6455139 | 0.79 | MDM2 (0.47) | MDM2TDP1L3MBTL1CES1CES2 | |
| SCHEMBL2336670 | 0.79 | PGR (0.52) | MDM2TDP1L3MBTL1CES1CES2 | |
| SCHEMBL5054802 | 0.79 | ALKBH5 (0.47) | MDM2TDP1L3MBTL1CES1CES2 | |
| SCHEMBL10658190 | 0.79 | MAPK1 (0.48) | MDM2TDP1L3MBTL1CES1CES2 | |
| SCHEMBL10658140 | 0.79 | CES1 (0.44) | MDM2TDP1L3MBTL1CES1CES2 | |
| SCHEMBL5214256 | 0.78 | GSK3B (0.47) | MDM2TDP1L3MBTL1CES1CES2 | |
| SCHEMBL4257686 | 0.78 | MDM2 (0.66) | MDM2TDP1L3MBTL1CES1CES2 | |
| SCHEMBL8780874 | 0.77 | CES1 (0.52) | MDM2TDP1L3MBTL1CES1CES2 | |
| SCHEMBL18705724 | 0.77 | MDM2 (0.48) | MDM2TDP1L3MBTL1CES1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167945-B1 | PHENYLETHYLAMINOPROPIOPHENONE DERIVATIVES, PROCESS FOR THEIR PREPARATION ET MEDICINES CONTAINING THEM | Troponwerke GmbH & Co. KG (DE) | 1988-04-13 | — | — | EP | disclosed |
| EP-0167945-A2 | Phenylethylaminopropiophenone derivatives, process for their preparation et medicines containing them | Troponwerke GmbH & Co. KG (DE) | 1986-01-15 | — | — | EP | disclosed |