Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 4/20 | 0.45 |
| ▸ | CES2 | O00748 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP12 | P39900 | 2/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11405755 | 0.89 | PTPN1 (0.50) | L3MBTL1LMNATSHRPTPN1GSK3B | |
| SCHEMBL10931231 | 0.84 | SRD5A2 (0.50) | MMP12HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL15158418 | 0.84 | PGR (0.44) | ALKBH5MDM2TDP1L3MBTL1CES1 | |
| SCHEMBL19328379 | 0.84 | CES2 (0.45) | L3MBTL1CES1CES2GSK3BMEN1 | |
| SCHEMBL5052427 | 0.82 | MMP2 (0.47) | CES1CES2PTPN1GSK3BMMP2 | |
| SCHEMBL19328352 | 0.82 | KMT2A (0.47) | CES1CES2LMNAGSK3BADRA2B | |
| SCHEMBL5055106 | 0.82 | CYP2C9 (0.51) | L3MBTL1CES1CES2LMNATSHR | |
| SCHEMBL19341769 | 0.81 | SLC6A2 (0.40) | MDM2CES1CES2TSHRGSK3B | |
| SCHEMBL5055096 | 0.81 | CES2 (0.51) | L3MBTL1CES1CES2LMNATSHR | |
| SCHEMBL4092391 | 0.80 | KCNA5 (0.48) | MDM2TDP1L3MBTL1TSHRPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586780-B1 | 2-ARYL IMIDAZO[1,2-A]PYRIDINE-3-ACETAMIDE DERIVATIVES, PREPARATION METHODS AND USE THEREOF | INST PHARMACOLOGY & TOXICOLOGY ACAD MILITARY MEDICAL SCIENCES PLA CHINA (CN) | 2017-03-22 | — | — | EP | disclosed |
| US-8980887-B2 | 2-aryl imidazo[1,2-a]pyridine-3-acetamide derivatives, preparation methods and uses thereof | INSTITUTE OF PHARMACOLOGY (CN) | 2015-03-17 | — | — | US | disclosed |
| US-20130203754-A1 | 2-Aryl Imidazo[1,2-a]Pyridine-3-Acetamide Derivatives, Preparation Methods and Uses Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2013-08-08 | — | — | US | disclosed |
| US-20080119456-A1 | Substituted Thiazoleacetic Acid as Crth2 Ligands | 7TM PHARMA A/S (DK) | 2008-05-22 | — | — | US | disclosed |
| US-20080119456-A1 | Substituted Thiazoleacetic Acid as Crth2 Ligands | 7TM PHARMA A/S (DK) | 2008-05-22 | — | — | US | disclosed |
| US-20080119456-A1 | Substituted Thiazoleacetic Acid as Crth2 Ligands | 7TM PHARMA A/S (DK) | 2008-05-22 | — | — | US | disclosed |
| EP-1758874-A1 | SUBSTITUTED THIAZOLEACETIC ACIDS AS CRTH2 LIGANDS | 7TM Pharma A/S (DK) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | disclosed |
| WO-2005116001-A1 | SUBSTITUTED THIAZOLEACETIC AS CRTH2 LIGANDS | 7TM PHARMA A/S (DK) | 2005-12-08 | — | — | WO | disclosed |
| EP-1170009-B1 | Thiazolybenzofuran derivatives and their use as SRS-A and leukotiene antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-04-07 | — | — | EP | disclosed |
| WO-1997027190-A1 | THIAZOLYLBENZOFURAN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-31 | — | — | WO | disclosed |
| US-5608109-A | AGRICULTURAL AND HORTICULTURAL INSECTICIDE | NIHON NOHYAKU CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| WO-1996015126-A1 | FURAN DERIVATIVES FOR INHIBITING PNEUMOCYSTIS CARINII PNEUMONIA, GIARDIA LAMBLIA AND CRYPTOSPORIDIUM PARVUM | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 1996-05-23 | — | — | WO | disclosed |
| CN-1107142-A | Hydrazine derivative and application of same | NIHON NOHYAKU CO LTD (JP) | 1995-08-23 | — | — | CN | disclosed |
| US-4447604-A | ANTICANCER AGENTS | JOHN WYETH & BROTHER LIMITED (GB) | 1984-05-08 | — | — | US | disclosed |
| EP-0020785-B1 | HEXAHYDRONAPHTHO(1',2':4,5)IMIDAZO(2,1-B)-THIAZOLE DERIVATIVES AND PROCESS FOR PREPARING SAME | TEIJIN LIMITED (JP) | 1982-11-24 | — | — | EP | disclosed |
| US-4347369-A | IMMUNOLOGY, ANTICARCINOGENIC, ANTIARTHRITIC, ANTHELMINTICS | TEIJIN LIMITED (JP) | 1982-08-31 | — | — | US | disclosed |
| US-4302585-A | IMMUNOSUPRESSANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-11-24 | — | — | US | disclosed |
| EP-0020785-A1 | HEXAHYDRONAPHTHO(1',2':4,5)IMIDAZO(2,1-b)-THIAZOLE DERIVATIVES AND PROCESS FOR PREPARING SAME | TEIJIN LIMITED (JP) | 1981-01-07 | — | — | EP | disclosed |
| US-4214089-A | Thiazolo[3,2-a]benzimidazoles, imidazo [2,1-b]thiazoles, and related compounds as antineoplastic agents, and enhancers of the immune response | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130203754-A1 | 2-Aryl Imidazo[1,2-a]Pyridine-3-Acetamide Derivatives, Preparation Methods and Uses Thereof | TSPO, SLC6A1, TBXA2R | ALKBH5 4704/4885MDM2 3017/4885TDP1 2234/4885 |
| US-20080119456-A1 | Substituted Thiazoleacetic Acid as Crth2 Ligands | HRH1, HRH2, HRH3 | ALKBH5 4825/4885MDM2 2482/4885TDP1 4837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.