Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.47 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.47 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CTRB1 | P17538 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CPA1 | P15085 | 2/20 | 0.44 |
| ▸ | CPA3 | P15088 | 2/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | CPB1 | P15086 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11266044 | 0.88 | MDM2 (0.51) | MDM2ALDH1A1KMT2ACPA1MMP2 | |
| SCHEMBL27719934 | 0.88 | RAB9A (0.56) | MDM2CYP1A2MAPTALDH1A1KMT2A | |
| SCHEMBL1303238 | 0.84 | ALDH1A1 (0.56) | MDM2CYP1A2MAPTALDH1A1KMT2A | |
| SCHEMBL27529019 | 0.82 | NR4A1 (0.62) | CYP1A2PTGS1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL1302717 | 0.82 | CES2 (0.53) | MDM2CYP1A2TDP1MAPTALDH1A1 | |
| SCHEMBL5610140 | 0.82 | MDM2 (0.68) | MDM2CYP1A2SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL17763412 | 0.81 | CYP1A2 (0.56) | MDM2CYP1A2SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL490844 | 0.81 | CYP1A2 (0.61) | MDM2CYP1A2SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL4826192 | 0.81 | CYP1A2 (0.61) | MDM2CYP1A2SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL4316458 | 0.81 | CYP1A2 (0.61) | MDM2CYP1A2SLC1A3SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-10036347-A | — | — | None | — | — | JP | disclosed |
| JP-5255256-A | — | — | None | — | — | JP | disclosed |
| US-20250051296-A1 | MODULATORS OF MYOCYTE LIPID ACCUMULATION AND INSULIN RESISTANCE AND METHODS OF USE THEREOF | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2025-02-13 | — | — | US | disclosed |
| US-12103917-B2 | Modulators of myocyte lipid accumulation and insulin resistance and methods of use thereof | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2024-10-01 | — | — | US | disclosed |
| US-20210300882-A1 | MODULATORS OF MYOCYTE LIPID ACCUMULATION AND INSULIN RESISTANCE AND METHODS OF USE THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-09-30 | — | — | US | disclosed |
| US-11028061-B2 | Modulators of myocyte lipid accumulation and insulin resistance and methods of use thereof | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-06-08 | — | — | US | disclosed |
| US-20180222874-A1 | MODULATORS OF MYOCYTE LIPID ACCUMULATION AND INSULIN RESISTANCE AND METHODS OF USE THEREOF | Sanford Bumham Prebys Medical Discovery Imstitute (US) | 2018-08-09 | — | — | US | disclosed |
| US-20180222874-A1 | MODULATORS OF MYOCYTE LIPID ACCUMULATION AND INSULIN RESISTANCE AND METHODS OF USE THEREOF | Sanford Bumham Prebys Medical Discovery Imstitute (US) | 2018-08-09 | — | — | US | disclosed |
| WO-2017019772-A1 | MODULATORS OF MYOCYTE LIPID ACCUMULATION AND INSULIN RESISTANCE AND METHODS OF USE THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2017-02-02 | — | — | WO | disclosed |
| WO-2017019772-A1 | MODULATORS OF MYOCYTE LIPID ACCUMULATION AND INSULIN RESISTANCE AND METHODS OF USE THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2017-02-02 | — | — | WO | disclosed |
| EP-1423113-A1 | NR1H4 NUCLEAR RECEPTOR BINDING COMPOUNDS | LION Bioscience AG (DE) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003097576-A2 | DIAMINO-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2003-11-27 | — | — | WO | disclosed |
| US-20030149087-A1 | NR1H4 nuclear receptor binding compounds | PHENEX PHARMACEUTICALS AG (DE) | 2003-08-07 | — | — | US | disclosed |
| WO-2003015777-A1 | NR1H4 NUCLEAR RECEPTOR BINDING COMPOUNDS | LION BIOSCIENCE AG (DE) | 2003-02-27 | — | — | WO | disclosed |
| EP-0802184-B1 | N-Benzyl-2-phenylindoles as estrogenic agents | WYETH CORP (US) | 2002-06-19 | — | — | EP | disclosed |
| CN-1309637-A | Compositions comprising 2-phenyl-indole compounds and estrogen formutations | AMERICAN HOME PROD (US) | 2001-08-22 | — | — | CN | disclosed |
| EP-1080073-A1 | COMPOSITIONS COMPRISING 2-PHENYL-INDOLE COMPOUNDS AND ESTROGEN FORMULATIONS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999059969-A1 | COMPOSITIONS COMPRISING 2-PHENYL-INDOLE COMPOUNDS AND ESTROGEN FORMULATIONS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-25 | — | — | WO | disclosed |
| JP-H1036347-A | ESTROGENLIKE AGENT | AMERICAN HOME PROD CORP | 1998-02-10 | — | — | JP | disclosed |
| JP-H05255256-A | PYRIDINIUM SALT AND PHOTO-SETTING COMPOSITION | COSMO SOGO KENKYUSHO:KK | 1993-10-05 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149087-A1 | NR1H4 nuclear receptor binding compounds | NR1H4, NR1H2, NR1H3 | MDM2 4487/4885CYP1A2 341/4885SLC1A3 1185/4885 |
| US-20250051296-A1 | MODULATORS OF MYOCYTE LIPID ACCUMULATION AND INSULIN RESISTANCE AND METHODS OF USE THEREOF | MYC, MYCBP, MLYCD | MDM2 408/4885CYP1A2 3187/4885SLC1A3 1230/4885 |
| US-20210300882-A1 | MODULATORS OF MYOCYTE LIPID ACCUMULATION AND INSULIN RESISTANCE AND METHODS OF USE THEREOF | MYC, MYCBP, MLYCD | MDM2 408/4885CYP1A2 3187/4885SLC1A3 1230/4885 |
| US-20180222874-A1 | MODULATORS OF MYOCYTE LIPID ACCUMULATION AND INSULIN RESISTANCE AND METHODS OF USE THEREOF | MYC, MYCBP, MLYCD | MDM2 408/4885CYP1A2 3187/4885SLC1A3 1230/4885 |
| US-11028061-B2 | Modulators of myocyte lipid accumulation and insulin resistance and methods of use thereof | MYC, MYCBP, MLYCD | MDM2 408/4885CYP1A2 3187/4885SLC1A3 1230/4885 |
| US-12103917-B2 | Modulators of myocyte lipid accumulation and insulin resistance and methods of use thereof | MYC, MYCBP, MLYCD | MDM2 408/4885CYP1A2 3187/4885SLC1A3 1230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.