Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 8/20 | 0.46 |
| ▸ | PREP | P48147 | 3/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.48 |
| ▸ | DPP4 | P27487 | 2/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL10653944 | 0.87 | ACE (0.51) | ACELMNASMN1; SMN2 | |
| Arginine SCHEMBL10654400 | 0.86 | ACE (0.46) | ACELMNAACE2SMN1; SMN2 | |
| Arginine SCHEMBL10656209 | 0.86 | ACE (0.44) | ACELMNAACE2SMN1; SMN2 | |
| Arginine SCHEMBL10866875 | 0.85 | ACE (0.40) | ACELMNAACE2 | |
| SCHEMBL10657907 | 0.85 | PREP (0.67) | PREPACELMNAACE2SMN1; SMN2 | |
| Arginine SCHEMBL10658646 | 0.84 | ACE (0.47) | ACELMNASMN1; SMN2 | |
| Arginine SCHEMBL7264429 | 0.84 | ACE (0.47) | ACELMNASMN1; SMN2 | |
| Arginine SCHEMBL7263661 | 0.84 | ACE (0.47) | ACELMNASMN1; SMN2 | |
| Arginine SCHEMBL10654662 | 0.84 | ACE (0.43) | ACELMNAACE2SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10657494 | 0.82 | DPP8 (0.54) | PREPDPP8DPP7DPP4DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4719200-A | Amino acid derivatives and antihypertensive drugs containing the same | AJINOMOTO CO., INC. (JP) | 1988-01-12 | — | — | US | disclosed |
| EP-0173510-A2 | Tripeptide derivatives for use as anti-hypertensive agents | AJINOMOTO CO., INC. (JP) | 1986-03-05 | — | — | EP | disclosed |