Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 6/20 | 0.47 |
| ▸ | TMPRSS11D | O60235 | 11/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 3/20 | 0.42 |
| ▸ | F10 | P00742 | 3/20 | 0.42 |
| ▸ | PLG | P00747 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL10653944 | 0.85 | ACE (0.51) | ACELMNASMN1; SMN2 | |
| Arginine SCHEMBL7263661 | 0.85 | ACE (0.47) | ACELMNASMN1; SMN2 | |
| Arginine SCHEMBL7264429 | 0.85 | ACE (0.47) | ACELMNASMN1; SMN2 | |
| SCHEMBL10656580 | 0.85 | ACE (0.57) | ACELMNASMN1; SMN2 | |
| Arginine SCHEMBL10653999 | 0.84 | PREP (0.51) | ACELMNASMN1; SMN2 | |
| SCHEMBL10658300 | 0.84 | ACE (0.52) | ACETMPRSS11DLMNASMN1; SMN2 | |
| SCHEMBL10658304 | 0.84 | ACE (0.52) | ACETMPRSS11DLMNASMN1; SMN2 | |
| Arginine SCHEMBL10654400 | 0.84 | ACE (0.46) | ACELMNASMN1; SMN2 | |
| Arginine SCHEMBL10656209 | 0.83 | ACE (0.44) | ACELMNASMN1; SMN2 | |
| Arginine SCHEMBL10866875 | 0.82 | ACE (0.40) | ACELMNAF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4719200-A | Amino acid derivatives and antihypertensive drugs containing the same | AJINOMOTO CO., INC. (JP) | 1988-01-12 | — | — | US | disclosed |
| EP-0173510-A2 | Tripeptide derivatives for use as anti-hypertensive agents | AJINOMOTO CO., INC. (JP) | 1986-03-05 | — | — | EP | disclosed |