Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.30 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10656710 | 0.88 | ALDH1A1 (0.36) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL10657805 | 0.82 | ALDH1A1 (0.40) | KDM4EALDH1A1HPGDHSD17B10CRHR1 | |
| SCHEMBL10658078 | 0.79 | SMN1; SMN2 (0.34) | KDM4EALDH1A1HSD17B10CRHR1HKDC1 | |
| SCHEMBL10654050 | 0.77 | KDM4E (0.36) | KDM4EALDH1A1HSD17B10CRHR1HKDC1 | |
| SCHEMBL9629009 | 0.76 | HPGD (0.44) | ALDH1A1HPGDHKDC1KMT2ATSHR | |
| SCHEMBL10377425 | 0.74 | HSD11B1 (0.34) | ALDH1A1HPGDHSD17B10MEN1KMT2A | |
| SCHEMBL10659321 | 0.73 | HKDC1 (0.41) | KDM4EHPGDHKDC1SMN1; SMN2LMNA | |
| SCHEMBL10656144 | 0.68 | POLB (0.38) | KDM4EALDH1A1HPGDHSD17B10CRHR1 | |
| SCHEMBL10657628 | 0.67 | CYP1A2 (0.35) | KDM4EALDH1A1HPGDHSD17B10HKDC1 | |
| SCHEMBL10379155 | 0.67 | HPGD (0.36) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |