SCHEMBL10657485

SCHEMBL10657485

C=CCc1ccc2c(c1)CCC=C2C#N

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 4/20 0.38
GABRB2 P47870 4/20 0.38
MAPT P10636 3/20 0.38
ALDH1A1 P00352 3/20 0.38
CNR2 P34972 3/20 0.38
PPARG P37231 2/20 0.38
PPARD Q03181 2/20 0.38
MEN1 O00255 2/20 0.38
GAA P10253 2/20 0.38
CNR1 P21554 2/20 0.38
KMT2A Q03164 2/20 0.38
KDM4E B2RXH2 1/20 0.38
ALDH2 P05091 1/20 0.38
AKR1B1 P15121 1/20 0.38
HPGD P15428 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
XDH P47989 1/20 0.36
CYP3A4 P08684 2/20 0.36
CYP1A2 P05177 1/20 0.36
PPARA Q07869 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9448042 0.72 PARP10 (0.40) CYP19A1MPO
SCHEMBL9448107 0.72 HTT (0.41) CYP19A1
SCHEMBL9523645 0.72 CYP11B2 (0.38) CYP3A4CYP19A1MPO
SCHEMBL8791849 0.69 MPO (0.59) MAPTALDH1A1GAAKDM4ECYP1A2
SCHEMBL10828054 0.68 ALDH1A1 (0.43) GABRA1GABRB2MAPTALDH1A1CNR2
SCHEMBL2775537 0.68 CES1 (0.39) MAPTALDH1A1KMT2AKDM4EHPGD
SCHEMBL10494619 0.66 XDH (0.48) GABRA1GABRB2MAPTALDH1A1CNR2
SCHEMBL7153161 0.65 ALDH1A1 (0.52) GABRA1GABRB2MAPTALDH1A1CNR2
SCHEMBL11767317 0.65 CES1 (0.50) GABRA1GABRB2MAPTALDH1A1CNR2
SCHEMBL24650531 0.64 XDH (0.47) GABRA1GABRB2MAPTALDH1A1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4764635-A Aromatization process ETHYL CORPORATION (US) 1988-08-16 US disclosed
US-4762943-A Aromatization process ETHYL CORPORATION (US) 1988-08-09 US disclosed
EP-0256849-A1 Aromatization process ETHYL CORPORATION (US) 1988-02-24 EP disclosed
EP-0254422-A1 Aromatization process ETHYL CORPORATION (US) 1988-01-27 EP disclosed