Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.48 |
| ▸ | RAB9A | P51151 | 8/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10945755 | 0.87 | MEN1 (0.44) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL10944127 | 0.85 | MEN1 (0.41) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL10737795 | 0.84 | MEN1 (0.42) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL10665892 | 0.83 | NPC1 (0.45) | NPC1RAB9APKMHPGDSMN1; SMN2 | |
| SCHEMBL10739363 | 0.83 | METAP1 (0.43) | NPC1RAB9APKMHPGDSMN1; SMN2 | |
| SCHEMBL10731537 | 0.83 | HTT (0.42) | HPGDSMN1; SMN2L3MBTL1MEN1KMT2A | |
| SCHEMBL10730705 | 0.83 | HSPA5 (0.43) | HPGDSMN1; SMN2L3MBTL1MEN1KMT2A | |
| SCHEMBL10660799 | 0.83 | HSPA5 (0.43) | PKMHPGDL3MBTL1MEN1KMT2A | |
| SCHEMBL10743173 | 0.80 | METAP1 (0.41) | NPC1RAB9APKMHPGDSMN1; SMN2 | |
| SCHEMBL10660913 | 0.80 | ALDH1A1 (0.43) | NPC1RAB9AHPGDSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4736033-A | Certain 1,3-dihydro-1-[heterocyclic)imino]-furo-[3,4-b]quinoline 9-ol compounds having analgesic and anti-inflammatory activity | ROUSSEL UCLAF (FR) | 1988-04-05 | — | — | US | disclosed |
| US-4596875-A | Reacting benzoxazole compound with amide to decyclize, cyclizing to form quinoline derivative | ROUSSEL UCLAF (FR) | 1986-06-24 | — | — | US | disclosed |
| US-4486438-A | 4-Hydroxy-3-quinoline-carboxylic acid derivatives | ROUSSEL UCLAF (FR) | 1984-12-04 | — | — | US | disclosed |