Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.33 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272419 | 0.84 | PDE3B (0.44) | PDE3BPDE3AMAPTDDB1CRBN | |
| SCHEMBL10665721 | 0.83 | PDE3B (0.39) | PDE3BPDE3AAKR1C3AKR1C1MAPT | |
| SCHEMBL9813079 | 0.81 | PDE3B (0.40) | PDE3BPDE3ADDB1CRBNROCK2 | |
| SCHEMBL9878558 | 0.77 | KDM4E (0.42) | PDE3BPDE3AMAPTCYP19A1ALDH1A1 | |
| SCHEMBL26857910 | 0.70 | AKR1C3 (0.50) | PDE3BPDE3AAKR1C3AKR1C1PAX8 | |
| SCHEMBL14630636 | 0.69 | TLR4 (0.37) | ALDH1A1TP53 | |
| SCHEMBL785036 | 0.68 | ESR2 (0.59) | PDE3BPDE3AMAPTDDB1CRBN | |
| SCHEMBL3988360 | 0.68 | AKR1C3 (0.47) | AKR1C3AKR1C1MAPTLMNA | |
| SCHEMBL791422 | 0.68 | MAPK1 (0.41) | MAPTALDH1A1TSHR | |
| SCHEMBL10534260 | 0.68 | CYP11B2 (0.45) | MAPTALDH1A1CYP3A4TSHRTHPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4782154-A | CARDIOTONICS | MITSUI TOATSU CHEMICALS, INC. (JP) | 1988-11-01 | — | — | US | disclosed |