Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272419 | 0.84 | PDE3B (0.44) | MCL1MAPTLMNA | |
| SCHEMBL10534260 | 0.83 | CYP11B2 (0.45) | KDM4ENPSR1MEN1KMT2AMAPT | |
| SCHEMBL6229686 | 0.80 | TSHR (0.50) | AKR1C3AKR1C1KDM4EMEN1KMT2A | |
| SCHEMBL7266417 | 0.78 | DDB1 (0.40) | MCL1KDM4EKMT2AMAPTLMNA | |
| SCHEMBL18366148 | 0.78 | TP53 (0.41) | AKR1C3AKR1C1KDM4EMEN1KMT2A | |
| SCHEMBL22048166 | 0.77 | SLC18A3 (0.45) | AKR1C3AKR1C1SRD5A1KDM4ESMN1; SMN2 | |
| SCHEMBL18585014 | 0.76 | SRD5A1 (0.49) | AKR1C3AKR1C1SRD5A1SMN1; SMN2SLC18A3 | |
| SCHEMBL13039616 | 0.75 | SRD5A1 (0.47) | AKR1C3AKR1C1SRD5A1SLC18A3GAA | |
| SCHEMBL8920951 | 0.74 | SRD5A1 (0.46) | AKR1C3AKR1C1SRD5A1SLC18A3GAA | |
| SCHEMBL6551213 | 0.73 | SRD5A1 (0.46) | AKR1C3AKR1C1SRD5A1SLC18A3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544691-B2 | Guanidine derivatives | ACTELION PHARMACEUTICALS, LTD. (CH) | 2009-06-09 | — | — | US | disclosed |
| EP-1663993-B1 | GUANIDINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-03-12 | — | — | EP | disclosed |
| US-20070123510-A1 | Guanidine derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2007-05-31 | — | — | US | disclosed |
| US-4845228-A | INTERMEDIATES FOR CARDIOTONIC AGENTS | MITSUI TOATSU CHEMICALS, INC. (JP) | 1989-07-04 | — | — | US | disclosed |
| US-4824952-A | CARDIOTONIC AGENTS | MITSUI TOATSU CHEMICALS, INC. (JP) | 1989-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123510-A1 | Guanidine derivatives | NPFFR1, NPFFR2, OGFR | AKR1C3 2529/4885AKR1C1 1647/4885MCL1 4439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.