SCHEMBL10666342

SCHEMBL10666342

CCOC(=O)c1ccc(Cl)c(NS(=O)(=O)c2nc3nc(OC)c(C)cn3n2)c1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
METTL3 Q86U44 1/20 0.38
IKBKB O14920 1/20 0.35
ALDH1A1 P00352 2/20 0.34
LMNA P02545 2/20 0.34
KDM4E B2RXH2 1/20 0.34
DCTPP1 Q9H773 1/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
TEAD2 Q15562 1/20 0.34
CYP4F2 P78329 1/20 0.33
CYP4A11 Q02928 1/20 0.33
TP53 P04637 1/20 0.33
HPGD P15428 1/20 0.33
HTT P42858 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
LGALS8 O00214 1/20 0.33
LGALS3 P17931 1/20 0.33
MAPK1 P28482 1/20 0.33
AURKB Q96GD4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10661779 0.93 PTGS2 (0.35) ALDH1A1LMNAKDM4EL3MBTL1
SCHEMBL10664683 0.91 MAPK1 (0.36) METTL3IKBKBALDH1A1LMNAKDM4E
SCHEMBL10663652 0.89 METTL3 (0.38) METTL3ALDH1A1LMNAKDM4EDCTPP1
SCHEMBL10667649 0.89 MAPT (0.34) LMNASMN1; SMN2
SCHEMBL10663355 0.86 DCTPP1 (0.36) ALDH1A1LMNAKDM4EDCTPP1NPC1
SCHEMBL10667753 0.85 DCTPP1 (0.35) ALDH1A1LMNAKDM4EDCTPP1NPC1
SCHEMBL10658673 0.85 SMN1; SMN2 (0.34) SMN1; SMN2
SCHEMBL9831367 0.84 IKBKB (0.38) METTL3IKBKBALDH1A1LMNAKDM4E
SCHEMBL10667923 0.83 ALDH1A1 (0.35) ALDH1A1LMNAKDM4EL3MBTL1
SCHEMBL9832056 0.83 METTL3 (0.38) METTL3IKBKBALDH1A1LMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4755212-A Novel substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides and compositions and method for inhibiting pollen formation in corn THE DOW CHEMICAL COMPANY (US) 1988-07-05 US disclosed
US-4741764-A SUPPRESSION OF NITRIFICATION OF AMMONIUM NITROGEN IN THE SOIL THE DOW CHEMICAL COMPANY (US) 1988-05-03 US disclosed
US-4740233-A Substituted 1,2,4-triazolo[1,5-a]-pyrimidine-2-sulfonamides and compositions and methods of controlling undesired vegetation and suppressing the nitrification of ammonium nitrogen in soil THE DOW CHEMICAL COMPANY (US) 1988-04-26 US disclosed