Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 5/20 | 0.64 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.64 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.64 |
| ▸ | PRCP | P42785 | 3/20 | 0.64 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.64 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.64 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.64 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.62 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29769890 | 0.80 | GRIN1 (0.64) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP | |
| SCHEMBL25398755 | 0.80 | GRIN1 (0.64) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP | |
| Rolicyclidine SCHEMBL517928 | 0.78 | SIGMAR1 (1.00) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP | |
| Phencyclidine SCHEMBL17008793 | 0.78 | SIGMAR1 (1.00) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP | |
| Phencyclidine SCHEMBL42022 | 0.78 | SIGMAR1 (1.00) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP | |
| SCHEMBL9153279 | 0.78 | SIGMAR1 (1.00) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP | |
| Phencyclidine SCHEMBL5166553 | 0.77 | SIGMAR1 (0.96) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP | |
| Phencyclidine SCHEMBL21777 | 0.77 | OPRM1 (1.00) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP | |
| SCHEMBL23595709 | 0.77 | GRIN1 (0.59) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP | |
| SCHEMBL23595717 | 0.77 | GRIN1 (0.59) | GRIN1GRIN2AGRIN2BSIGMAR1PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4762846-A | Metaphit and related compounds as acylating agents for the (3H)phencyclidine receptors | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1988-08-09 | — | — | US | disclosed |