Phencyclidine

Phencyclidine

SCHEMBL21777

Cl.c1ccc(C2(N3CCCCC3)CCCCC2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Phencyclidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OPRM1 known ✓ P35372 3/20 1.00
OPRD1 known ✓ P41143 1/20 1.00
GRIN1 known ✓ Q05586 5/20 0.96
GRIN2A known ✓ Q12879 5/20 0.96
GRIN2B known ✓ Q13224 5/20 0.96
SIGMAR1 known ✓ Q99720 5/20 0.96
GRIN2D known ✓ O15399 1/20 0.96
GRIN3B known ✓ O60391 1/20 0.96
SLC6A2 known ✓ P23975 1/20 0.96
SLC6A4 known ✓ P31645 1/20 0.96
SLC6A3 known ✓ Q01959 1/20 0.96
KCNH2 known ✓ Q12809 1/20 0.96
GRIN2C known ✓ Q14957 1/20 0.96
GRIN3A known ✓ Q8TCU5 1/20 0.96
PRCP P42785 3/20 0.96
CYP2B6 P20813 1/20 0.96
MEN1 O00255 3/20 0.53
KMT2A Q03164 3/20 0.53
TP53 P04637 1/20 0.53
CYP1A2 P05177 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Rolicyclidine SCHEMBL517928 0.98 SIGMAR1 (1.00) OPRM1OPRD1GRIN1GRIN2AGRIN2B
SCHEMBL9153279 0.98 SIGMAR1 (1.00) OPRM1OPRD1GRIN1GRIN2AGRIN2B
Phencyclidine SCHEMBL42022 0.98 SIGMAR1 (1.00) OPRM1OPRD1GRIN1GRIN2AGRIN2B
Phencyclidine SCHEMBL17008793 0.98 SIGMAR1 (1.00) OPRM1OPRD1GRIN1GRIN2AGRIN2B
Phencyclidine SCHEMBL5166553 0.96 SIGMAR1 (0.96) OPRM1OPRD1GRIN1GRIN2AGRIN2B
Phencyclidine SCHEMBL9431514 0.94 SIGMAR1 (0.92) OPRM1OPRD1GRIN1GRIN2AGRIN2B
SCHEMBL3407261 0.94 GRIN1 (0.92) OPRM1OPRD1GRIN1GRIN2AGRIN2B
SCHEMBL28282384 0.92 GRIN1 (0.88) OPRM1OPRD1GRIN1GRIN2AGRIN2B
Phencyclidine SCHEMBL28239746 0.91 GRIN1 (0.86) OPRM1OPRD1GRIN1GRIN2AGRIN2B
Phencyclidine SCHEMBL28294388 0.91 SIGMAR1 (0.86) OPRM1OPRD1GRIN1GRIN2AGRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3412 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119613580-A Gardenia polysaccharide, and preparation method and application thereof 河南中医药大学 2025-03-14 CN claimed
US-12022895-B1 Heated glove PAGE TOKOA (US) 2024-07-02 US claimed
WO-2024108111-A1 COMPOSITIONS AND METHODS FOR DETECTING UROLOGICAL CANCER MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2024-05-23 WO claimed
EP-4370466-A1 CARTRIDGE SYSTEM COMPRISING A CARTRIDGE CLOSED BY A VALVE Freezio AG (CH) 2024-05-22 EP claimed
EP-4355178-A1 ARTIFICIAL TREES WITH WIRELESS POWER TRANSMISSION Belgravia Wood Limited (HK) 2024-04-24 EP claimed
WO-2024039764-A2 EPITRANSCRIPTOMIC ANALYSIS OF GLIOMA OHIO STATE INNOVATION FOUNDATION (US) 2024-02-22 WO claimed
US-11825891-B1 Gloves with finger-warming insert pockets WILSON ROBERT DEAN (US) 2023-11-28 US claimed
EP-3887115-B1 METHOD FOR IMPREGNATING A FIBROUS MATERIAL IN AN INTERPENETRATED FLUIDISED BED ARKEMA FRANCE (FR) 2023-11-22 EP claimed
EP-3572088-B1 A PANAX PLANT EXTRACT AND PHARMACEUTICAL COMPOSITION AND USE THEREOF SHANGHAI HUIYU BIOMEDICAL TECH CO LTD (CN) 2023-08-16 EP claimed
CN-116199626-A Method for removing aripiprazole BQB impurities 浙江华海药业股份有限公司 2023-06-02 CN claimed
EP-0304005-A1 Fiber reinforced composite and process for its preparation Pelzer, Helmut (DE) 1989-02-22 EP claimed
US-4733413-A Glove construction and method of making SHELBY GROUP INTERNATIONAL, INC. (US) 1988-03-29 US claimed
EP-0258670-A1 Impregnated-layers component SIEMENS AKTIENGESELLSCHAFT (DE) 1988-03-09 EP claimed
US-4585201-A Christmas tree stand PURSELL RICHARD A 1986-04-29 US claimed
US-4497162-A Combine harvester KUBOTA, LTD. (JP) 1985-02-05 US claimed
EP-0006823-B1 BARGE EQUIPPED WITH A DEVICE FOR COLLECTING FLOATING MATTER Société d'Exploitation des Procédés EGMO (S.E.P. - EGMO) SARL (FR) 1981-10-07 EP claimed
WO-1981002745-A1 METHOD FOR REDUCING BY DIALYSIS THE ALCOHOL CONTENT OF FERMENTED DRINKS AKZO GMBH (DE) 1981-10-01 WO claimed
US-4217303-A UNSATURATED HYDROCARBON, ADDUCT, UNSATURATED DINITRILE, BY-PRODUCT INHIBITION PHILLIPS PETROLEUM COMPANY (US) 1980-08-12 US claimed
EP-0006888-A1 SYSTEM FOR TRANSPORTING AND STORING BEVERAGES CONTAINING CARBONIC ACID, PARTICULARY BEER BIER-DRIVE AG (CH) 1980-01-23 EP claimed
WO-1979000092-A1 SYSTEM FOR TRANSPORTING AND STORING BEVERAGES CONTAINING CARBONIC ACID,PARTICULARLY BEER BIER DRIVE AG (DE) 1979-03-08 WO claimed