Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.44 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.44 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.44 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4242570 | 0.82 | ALDH1A1 (0.62) | KDM4EALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL2387794 | 0.82 | NPC1 (0.57) | KDM4EALDH1A1MAOBMEN1KMT2A | |
| SCHEMBL8652676 | 0.82 | LMNA (0.45) | CYP1A2KDM4EALDH1A1CTDSP1MAOB | |
| SCHEMBL86139 | 0.82 | ALDH1A1 (0.47) | ALDH1A1TSHRL3MBTL1TAAR1SMN1; SMN2 | |
| SCHEMBL27905842 | 0.82 | POLB (0.47) | POLBCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL148596 | 0.82 | THRB (0.47) | POLBCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL28327983 | 0.81 | TSHR (0.51) | POLBCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL10053298 | 0.81 | L3MBTL1 (0.44) | POLBKDM4EALDH1A1L3MBTL1LMNA | |
| SCHEMBL5691929 | 0.81 | ALDH1A1 (0.41) | ALDH1A1TSHRL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL86418 | 0.81 | KMT2A (0.55) | ALDH1A1GAAMAOAMAOBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110590606-B | Process for preparing pyrimidylcyclopentane compounds | 豪夫迈·罗氏有限公司 | 2023-02-17 | — | — | CN | disclosed |
| CN-105899492-B | Process for preparing pyrimidylcyclopentane compounds | 豪夫迈·罗氏有限公司 | 2021-08-24 | — | — | CN | disclosed |
| CN-112898210-A | Process for preparing pyrimidylcyclopentane compounds | 豪夫迈·罗氏有限公司 | 2021-06-04 | — | — | CN | disclosed |
| CN-110590606-A | Process for preparing pyrimidylcyclopentane compounds | 豪夫迈·罗氏有限公司 | 2019-12-20 | — | — | CN | disclosed |
| CN-102015706-A | Imidazolidinone derivatives as 11B-HSD1 inhibitors | HOFFMANN LA ROCHE | 2011-04-13 | — | — | CN | disclosed |
| US-20110007123-A1 | THERMAL TRANSFER SHEET AND IMAGE FORMATION METHOD USING SAME | FUJIFILM CORPORATION (JP) | 2011-01-13 | — | — | US | disclosed |
| US-7825149-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2010-11-02 | — | — | US | disclosed |
| US-20090312326-A1 | SUBSTITUTED IMIDAZOLES | PFIZER LIMITED (GB) | 2009-12-17 | — | — | US | disclosed |
| US-7592362-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-09-22 | — | — | US | disclosed |
| US-7547718-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-06-16 | — | — | US | disclosed |
| US-20080125473-A1 | SUBSTITUTED IMIDAZOLES | PFIZER LIMITED (GB) | 2008-05-29 | — | — | US | disclosed |
| US-20080119536-A1 | SUBSTITUTED IMIDAZOLES | PFIZER LIMITED (GB) | 2008-05-22 | — | — | US | disclosed |
| US-20070167506-A1 | SUBSTITUTED IMIDAZOLES | PFIZER INC. (US) | 2007-07-19 | — | — | US | disclosed |
| CN-1882347-A | AKT protein kinase inhibitors | ARRAY BIOPHARMA INC (US) | 2006-12-20 | — | — | CN | disclosed |
| CN-1151140-C | Glucokinase activators | - | 2004-05-26 | — | — | CN | disclosed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | disclosed |
| US-5846989-A | Benzothiazolone derivatives | ASTRA PHARMACEUTICALS LIMITED (GB) | 1998-12-08 | — | — | US | disclosed |
| US-4339951-A | Tempeature measurement and display of indicia using thermochromic polyacetylenes | ALLIED CORPORATION (US) | 1982-07-20 | — | — | US | disclosed |
| US-4242440-A | Thermochromic polyacetylenes used in laser beam recording method | ALLIED CHEMICAL CORPORATION (US) | 1980-12-30 | — | — | US | disclosed |
| US-4215208-A | Thermochromic polyacetylenes containing urethane groups | ALLIED CHEMICAL CORPORATION (US) | 1980-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125473-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | SIRT2 1457/4885CNR1 1586/4885POLB 3099/4885 |
| US-20090312326-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | SIRT2 1457/4885CNR1 1586/4885POLB 3099/4885 |
| US-20070167506-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | SIRT2 1457/4885CNR1 1586/4885POLB 3099/4885 |
| US-20080119536-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | SIRT2 1457/4885CNR1 1586/4885POLB 3099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.