Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL109899 | 0.75 | SMYD3 (0.40) | KDM4EPKM | |
| SCHEMBL2781825 | 0.74 | KMT2A (0.40) | — | |
| SCHEMBL13485303 | 0.69 | NAMPT (0.53) | NAMPTGRM1GRM4KDM4EPKM | |
| SCHEMBL108217 | 0.69 | NAMPT (0.42) | NAMPTGRM1GRM4 | |
| SCHEMBL17971458 | 0.68 | NAMPT (0.49) | NAMPTGRM1GRM4KDM4EPKM | |
| SCHEMBL109203 | 0.68 | SIRT6 (0.41) | — | |
| SCHEMBL107379 | 0.67 | — | — | |
| SCHEMBL106400 | 0.66 | PSMB8 (0.40) | — | |
| Water SCHEMBL11526103 | 0.65 | CA12 (0.35) | — | |
| SCHEMBL4002227 | 0.65 | ROCK1 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424869-A1 | 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | Glaxo Group Limited (GB) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010125102-A1 | 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-11-04 | — | — | WO | disclosed |