Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 11/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 10/20 | 0.51 |
| ▸ | GSK3B | P49841 | 8/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.51 |
| ▸ | PRKG1 | Q13976 | 8/20 | 0.51 |
| ▸ | RPS6KA5 | O75582 | 7/20 | 0.51 |
| ▸ | PKN2 | Q16513 | 7/20 | 0.51 |
| ▸ | GSK3A | P49840 | 7/20 | 0.51 |
| ▸ | AKT1 | P31749 | 6/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.51 |
| ▸ | PRKG2 | Q13237 | 6/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.51 |
| ▸ | SGK2 | Q9HBY8 | 6/20 | 0.51 |
| ▸ | PRKACA | P17612 | 6/20 | 0.51 |
| ▸ | PRKX | P51817 | 6/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.51 |
| ▸ | CDC42BPA | Q5VT25 | 5/20 | 0.51 |
| ▸ | CDK1 | P06493 | 3/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL109823 | 0.71 | KMT2A (0.42) | MAPK1CSF1RHDAC1POLB | |
| SCHEMBL108573 | 0.71 | ACACB (0.34) | HDAC1HDAC6CSNK1D | |
| SCHEMBL9824905 | 0.71 | POLB (0.51) | HDAC1HDAC6SMN1; SMN2NPC1RAB9A | |
| SCHEMBL109511 | 0.69 | HSPA9 (0.44) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL3997806 | 0.69 | KDM4E (0.77) | ROCK1ROCK2GSK3BCLK4PRKG1 | |
| SCHEMBL2781825 | 0.69 | KMT2A (0.40) | CSF1RHDAC1HDAC6 | |
| SCHEMBL108808 | 0.69 | RAB9A (0.46) | HDAC1HDAC6SMN1; SMN2NPC1RAB9A | |
| SCHEMBL106400 | 0.69 | PSMB8 (0.40) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4578937 | 0.68 | KMT2A (0.52) | ROCK1ROCK2GSK3BCLK4PRKG1 | |
| SCHEMBL3093010 | 0.68 | ROCK1 (1.00) | ROCK1ROCK2GSK3BCLK4PRKG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071576-A1 | 5-ARYL-1,3,4-OXADIAZOLE-2-AMINES AS NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2009-06-11 | — | — | WO | disclosed |