Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | RECQL | P46063 | 3/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | APP | P05067 | 5/20 | 0.48 |
| ▸ | IAPP | P10997 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 4/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8257343 | 1.00 | ALOX15 (0.57) | ALOX15KDM4ERECQLHIF1AHSD17B10 | |
| Hydrochloric Acid SCHEMBL1148892 | 0.99 | ALOX15 (0.56) | ALOX15KDM4ERECQLHIF1AHSD17B10 | |
| SCHEMBL1070169 | 0.96 | ALOX15 (0.56) | ALOX15KDM4ERECQLHIF1AHSD17B10 | |
| SCHEMBL15275681 | 0.95 | HSD17B10 (0.55) | ALOX15KDM4ERECQLHIF1AHSD17B10 | |
| SCHEMBL11754702 | 0.95 | HSD17B10 (0.55) | ALOX15KDM4ERECQLHIF1AHSD17B10 | |
| SCHEMBL28115688 | 0.95 | HSD17B10 (0.55) | ALOX15KDM4ERECQLHIF1AHSD17B10 | |
| SCHEMBL6140024 | 0.92 | ALOX15 (0.60) | ALOX15KDM4ERECQLHIF1AHSD17B10 | |
| SCHEMBL15679070 | 0.92 | ALOX15 (0.60) | ALOX15KDM4ERECQLHIF1AHSD17B10 | |
| SCHEMBL16135503 | 0.90 | ALOX15 (0.62) | ALOX15KDM4ERECQLHIF1AHSD17B10 | |
| SCHEMBL22959852 | 0.90 | ALOX15 (0.62) | ALOX15KDM4ERECQLHIF1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11969401-B2 | Compositions and methods for treating or limiting development of age-related macular degeneration | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2024-04-30 | — | — | US | disclosed |
| US-20220023245-A1 | COMPOSITIONS AND METHODS FOR TREATING OR LIMITING DEVELOPMENT OF AGE-RELATED MACULAR DEGENERATION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-01-27 | — | — | US | disclosed |
| EP-3917504-A1 | COMPOSITIONS AND METHODS FOR TREATING OR LIMITING DEVELOPMENT OF AGE-RELATED MACULAR DEGENERATION | Arizona Board of Regents on behalf of the University of Arizona (US) | 2021-12-08 | — | — | EP | disclosed |
| CN-109956868-B | Phenyl carboxylic acid derivatives, preparation method and application thereof | 中国科学院上海药物研究所 | 2020-10-09 | — | — | CN | disclosed |
| WO-2020160256-A1 | COMPOSITIONS AND METHODS FOR TREATING OR LIMITING DEVELOPMENT OF AGE-RELATED MACULAR DEGENERATION | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2020-08-06 | — | — | WO | disclosed |
| US-20180008671-A1 | PROLONGED ANTI-DIABETIC EFFECT OF FIBROBLAST GROWTH FACTOR 1 (FGF1) | UNIVERSITY OF WASHINGTON (US) | 2018-01-11 | — | — | US | disclosed |
| US-9861600-B2 | Methods and compositions for treating and identifying compounds to treat age-related macular degeneration treatment | Arizona Board of Regents, A Body Corporate Of The State Of Arizona Acting For An On Behalf Of The University of Arizona (US) | 2018-01-09 | — | — | US | disclosed |
| US-20170224637-A1 | INTRANSAL DELIVERY OF CURCUMIN | DePuy Synthes Products, Inc. (US) | 2017-08-10 | — | — | US | disclosed |
| US-20160374960-A1 | Method of Topically Administering a Curcumin Derivative | JOHNSON & JOHNSON CONSUMER, INC. | 2016-12-29 | — | — | US | disclosed |
| WO-2016130683-A1 | PROLONGED ANTI-DIABETIC EFFECT OF FIBROBLAST GROWTH FACTOR 1 (FGF1) | UNIVERSITY OF WASHINGTON (US) | 2016-08-18 | — | — | WO | disclosed |
| US-20090326275-A1 | USE OF NITROGEN-CONTAINING CURCUMIN ANALOGS FOR THE TREATMENT OF ALZHEIMERS DISEASE | DEPUY SPINE, LLC | 2009-12-31 | — | — | US | disclosed |
| WO-2009158407-A1 | IONTOPHORETIC DELIVERY OF CURCUMIN AND CURCUMIN ANALOGS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | CODMAN & SHURTLEFF, INC. (US) | 2009-12-30 | — | — | WO | disclosed |
| EP-2136797-A2 | INTRANASALLY ADMINISTERING CURCUMIN IN A BOLUS OF HELIUM GAS TO TREAT ALZHEIMER'S DISEASE | Codman & Shurtleff Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2009129497-A2 | METHODS AND COMPOSITIONS FOR TREATING AND IDENTIFYING COMPOUNDS TO TREAT AGE-RELATED MACULAR DEGENERATION | ARIZONA BOARD OF REGENTS, A BODY CORP. OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2009-10-22 | — | — | WO | disclosed |
| WO-2009101616-A1 | NOVEL CONJUGATES FOR TREATING NEURODEGENERATIVE DISEASES AND DISORDERS | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2009-08-20 | — | — | WO | disclosed |
| US-20090087385-A1 | Intranasally administering curcumin in a bolus of helium gas to treat alzheimers disease | CODMAN & SHURTLEFF, INC. | 2009-04-02 | — | — | US | disclosed |
| WO-2008131059-A2 | INTRANASALLY ADMINISTERING CURCUMIN IN A BOLUS OF HELIUM GAS TO TREAT ALZHEIMER'S DISEASE | CODMAN & SHURTLEFF, INC. (US) | 2008-10-30 | — | — | WO | disclosed |
| US-20080076821-A1 | INTRANASALLY ADMINISTERING CURCUMIN PRODRUGS TO THE BRAIN TO TREAT ALZHEIMER'S DISEASE | DePuy Synthes Products, Inc. | 2008-03-27 | — | — | US | disclosed |
| WO-1997016181-A1 | METHOD FOR THE INTRANASAL ADMINISTRATION OF L-DOPA PRODRUGS | UNIVERSITY OF KENTUCKY (US) | 1997-05-09 | — | — | WO | disclosed |
| US-4021538-A | Method for producing pigmentation in hair or skin | YU RUEY J | 1977-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220023245-A1 | COMPOSITIONS AND METHODS FOR TREATING OR LIMITING DEVELOPMENT OF AGE-RELATED MACULAR DEGENERATION | MTNR1A, MC1R, MTNR1B | ALOX15 674/4885KDM4E 3969/4885RECQL 3491/4885 |
| US-20160374960-A1 | Method of Topically Administering a Curcumin Derivative | S100A11, S100A4, S100A6 | ALOX15 48/4885KDM4E 1183/4885RECQL 4232/4885 |
| US-20090326275-A1 | USE OF NITROGEN-CONTAINING CURCUMIN ANALOGS FOR THE TREATMENT OF ALZHEIMERS DISEASE | SLC1A3, SLC1A1, SLC1A2 | ALOX15 350/4885KDM4E 3397/4885RECQL 4560/4885 |
| US-11969401-B2 | Compositions and methods for treating or limiting development of age-related macular degeneration | MTNR1A, MC1R, MTNR1B | ALOX15 674/4885KDM4E 3969/4885RECQL 3491/4885 |
| US-20170224637-A1 | INTRANSAL DELIVERY OF CURCUMIN | FABP7, FABP2, NDUFB5 | ALOX15 502/4885KDM4E 2958/4885RECQL 4218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.